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Review of structura...
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Cárdenas, MaritéMalmö universitet,Malmö University,Basque Foundation for Science,CSIC Spanish National Research Council,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Univ Basque Country & Consejo Super Invest Cient, Biofis Inst, UPV EHU CSIC, Leioa 48940, Spain.;Basque Fdn Sci, IKERBASQUE, Bilbao, Spain.
(författare)
Review of structural design guiding the development of lipid nanoparticles for nucleic acid delivery
- Artikel/kapitelEngelska2023
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Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:e3cc219f-0798-48ed-ad48-f6f65cc9e9e0
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https://lup.lub.lu.se/record/e3cc219f-0798-48ed-ad48-f6f65cc9e9e0URI
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https://doi.org/10.1016/j.cocis.2023.101705DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-61924URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:for swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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Lipid nanoparticles (LNPs) are the most versatile and successful gene delivery systems, notably highlighted by their use in vaccines against COVID-19. LNPs have a well-defined core–shell structure, each region with its own distinctive compositions, suited for a wide range of in vivo delivery applications. Here, we discuss how a detailed knowledge of LNP structure can guide LNP formulation to improve the efficiency of delivery of their nucleic acid payload. Perspectives are detailed on how LNP structural design can guide more efficient nucleic acid transfection. Views on key physical characterization techniques needed for such developments are outlined including opinions on biophysical approaches both correlating structure with functionality in biological fluids and improving their ability to escape the endosome and deliver they payload.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Campbell, Richard A.University of Manchester,Univ Manchester, Fac Biol Med & Hlth, Div Pharm & Optometry, Manchester M13 9PT, England.
(författare)
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Yanez Arteta, MariannaAstraZeneca, Adv Drug Delivery Pharmaceut Sci, R&D, S-43183 Gothenburg, Sweden.
(författare)
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Lawrence, M. JayneUniversity of Manchester,Univ Manchester, Fac Biol Med & Hlth, Div Pharm & Optometry, Manchester M13 9PT, England.
(författare)
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Sebastiani, FedericaLund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Polytechnic University of Milan,Politecn Milan, Dept Chem Mat & Chem Engn, I-20131 Milan, Italy.;Lund Univ, Dept Chem, Div Phys Chem, S-22100 Lund, Sweden.(Swepub:lu)fe3110se
(författare)
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Malmö UniversityBasque Foundation for Science
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Current Opinion in Colloid and Interface Science: Elsevier661359-02941879-0399
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