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  • Rosa, Fábio F.Lund University,Lunds universitet,Cellulär omprogrammering i hematopoes och immunitet,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Cell Reprogramming in Hematopoiesis and Immunity,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,University of Coimbra (author)

Direct reprogramming of fibroblasts into antigen-presenting dendritic cells

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • American Association for the Advancement of Science (AAAS),2018

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:e55030ac-0449-4fb3-b8ca-503cbf8c6911
  • https://lup.lub.lu.se/record/e55030ac-0449-4fb3-b8ca-503cbf8c6911URI
  • https://doi.org/10.1126/sciimmunol.aau4292DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Ectopic expression of transcription factors has been used to reprogram differentiated somatic cells toward pluripotency or to directly reprogram them to other somatic cell lineages. This concept has been explored in the context of regenerative medicine. Here, we set out to generate dendritic cells (DCs) capable of presenting antigens from mouse and human fibroblasts. By screening combinations of 18 transcription factors that are expressed in DCs, we have identified PU.1, IRF8, and BATF3 transcription factors as being sufficient to reprogram both mouse and human fibroblasts to induced DCs (iDCs). iDCs acquire a conventional DC type 1-like transcriptional program, with features of interferon-induced maturation. iDCs secrete inflammatory cytokines and have the ability to engulf, process, and present antigens to T cells. Furthermore, we demonstrate that murine iDCs generated here were able to cross-present antigens to CD8+ T cells. Our reprogramming system should facilitate better understanding of DC specification programs and serve as a platform for the development of patient-specific DCs for immunotherapy.

Subject headings and genre

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  • Pires, Cristiana F.Lund University,Lunds universitet,Cellulär omprogrammering i hematopoes och immunitet,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Cell Reprogramming in Hematopoiesis and Immunity,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,University of Coimbra(Swepub:lu)cr5211fe (author)
  • Kurochkin, IliaSkolkovo Institute of Science and Technology (author)
  • Ferreira, Alexandra G.Lund University,Lunds universitet,Cellulär omprogrammering i hematopoes och immunitet,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Cell Reprogramming in Hematopoiesis and Immunity,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,University of Coimbra(Swepub:lu)al1508fe (author)
  • Gomes, Andreia M.University of Coimbra (author)
  • Palma, Luís G.University of Coimbra (author)
  • Shaiv, KritikaUniversity of Coimbra (author)
  • Solanas, LauraUniversity of Coimbra (author)
  • Azenha, CláudiaUniversity of Coimbra (author)
  • Papatsenko, DmitriSkolkovo Institute of Science and Technology (author)
  • Schulz, OliverFrancis Crick Institute (author)
  • E Sousa, Caetano ReisFrancis Crick Institute (author)
  • Pereira, Carlos FilipeLund University,Lunds universitet,Cellulär omprogrammering i hematopoes och immunitet,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Cell Reprogramming in Hematopoiesis and Immunity,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,University of Coimbra(Swepub:lu)ca4155pe (author)
  • Cellulär omprogrammering i hematopoes och immunitetForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Science Immunology: American Association for the Advancement of Science (AAAS)3:302470-9468

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