Search: WFRF:(Franklin C. S.)
> (2020-2024) >
α-Synuclein seed am...
-
Levin, JohannesGerman Center for Neurodegenerative Diseases (DZNE), Bonn,Munich Cluster for Systems Neurology,University Hospital Munich
(author)
α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden
- Article/chapterEnglish2024
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:e5650208-9c96-45e7-a54e-1a3acec898e0
-
https://lup.lub.lu.se/record/e5650208-9c96-45e7-a54e-1a3acec898e0URI
-
https://doi.org/10.1002/alz.13818DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
INTRODUCTION: Amyloid beta and tau pathology are the hallmarks of sporadic Alzheimer's disease (AD) and autosomal dominant AD (ADAD). However, Lewy body pathology (LBP) is found in ≈ 50% of AD and ADAD brains. METHODS: Using an α-synuclein seed amplification assay (SAA) in cerebrospinal fluid (CSF) from asymptomatic (n = 26) and symptomatic (n = 27) ADAD mutation carriers, including 12 with known neuropathology, we investigated the timing of occurrence and prevalence of SAA positive reactivity in ADAD in vivo. RESULTS: No asymptomatic participant and only 11% (3/27) of the symptomatic patients tested SAA positive. Neuropathology revealed LBP in 10/12 cases, primarily affecting the amygdala or the olfactory areas. In the latter group, only the individual with diffuse LBP reaching the neocortex showed α-synuclein seeding activity in CSF in vivo. DISCUSSION: Results suggest that in ADAD LBP occurs later than AD pathology and often as amygdala- or olfactory-predominant LBP, for which CSF α-synuclein SAA has low sensitivity. Highlights: Cerebrospinal fluid (CSF) real-time quaking-induced conversion (RT-QuIC) detects misfolded α-synuclein in ≈ 10% of symptomatic autosomal dominant Alzheimer's disease (ADAD) patients. CSF RT-QuIC does not detect α-synuclein seeding activity in asymptomatic mutation carriers. Lewy body pathology (LBP) in ADAD mainly occurs as olfactory only or amygdala-predominant variants. LBP develops late in the disease course in ADAD. CSF α-synuclein RT-QuIC has low sensitivity for focal, low-burden LBP.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Baiardi, Simone
(author)
-
Quadalti, Corinne
(author)
-
Rossi, Marcello
(author)
-
Mammana, Angela
(author)
-
Vöglein, JonathanGerman Center for Neurodegenerative Diseases (DZNE), Bonn,University Hospital Munich
(author)
-
Bernhardt, AlexanderUniversity Hospital Munich,German Center for Neurodegenerative Diseases (DZNE), Bonn
(author)
-
Perrin, Richard J.Washington University in St. Louis
(author)
-
Jucker, MathiasGerman Center for Neurodegenerative Diseases (DZNE), Bonn,University of Tübingen
(author)
-
Preische, OliverUniversity of Tübingen,German Center for Neurodegenerative Diseases (DZNE), Bonn
(author)
-
Hofmann, AnnaUniversity of Tübingen,German Center for Neurodegenerative Diseases (DZNE), Bonn
(author)
-
Höglinger, Günter U.German Center for Neurodegenerative Diseases (DZNE), Bonn,Munich Cluster for Systems Neurology,University Hospital Munich
(author)
-
Cairns, Nigel J.University of Exeter
(author)
-
Franklin, Erin E.Washington University in St. Louis
(author)
-
Chrem, PatricioFundacion Para La Lucha Contra Las Enfermedades Neurologicas de La Infancia (FLENI)
(author)
-
Cruchaga, CarlosWashington University in St. Louis
(author)
-
Berman, Sarah B.University of Pittsburgh
(author)
-
Chhatwal, Jasmeer P.Harvard Medical School
(author)
-
Daniels, AlishaWashington University in St. Louis
(author)
-
Day, Gregory S.Mayo Clinic Florida
(author)
-
Ryan, Natalie S.University College London
(author)
-
Goate, Alison M.Icahn School of Medicine at Mount Sinai
(author)
-
Gordon, Brian A.Washington University in St. Louis
(author)
-
Huey, Edward D.Brown University
(author)
-
Ibanez, LauraWashington University in St. Louis
(author)
-
Karch, Celeste M.Washington University in St. Louis
(author)
-
Lee, Jae Hong
(author)
-
Llibre-Guerra, JorgeWashington University in St. Louis
(author)
-
Lopera, Francisco
(author)
-
Masters, Colin L.University of Melbourne
(author)
-
Morris, John C.Washington University in St. Louis
(author)
-
Noble, James M.Columbia University
(author)
-
Renton, Alan E.Icahn School of Medicine at Mount Sinai
(author)
-
Roh, Jee Hoon
(author)
-
Frosch, Matthew P.Massachusetts General Hospital
(author)
-
Keene, C. DirkUniversity of Washington
(author)
-
McLean, CatrionaAlfred Health
(author)
-
Sanchez-Valle, RaquelHospital Clínic of Barcelona
(author)
-
Schofield, Peter R.University of New South Wales,Neuroscience Research Australia (NeuRA)
(author)
-
Supnet-Bell, CharleneWashington University in St. Louis
(author)
-
Xiong, ChengjieWashington University in St. Louis
(author)
-
Giese, Armin
(author)
-
Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital(Swepub:lu)mphy-ohn
(author)
-
Bateman, Randall J.Washington University in St. Louis
(author)
-
McDade, EricWashington University in St. Louis
(author)
-
Parchi, Piero
(author)
-
German Center for Neurodegenerative Diseases (DZNE), BonnMunich Cluster for Systems Neurology
(creator_code:org_t)
-
Dominantly Inherited Alzheimer Network
Related titles
-
In:Alzheimer's and Dementia1552-5260
Internet link
Find in a library
To the university's database
- By the author/editor
-
Levin, Johannes
-
Baiardi, Simone
-
Quadalti, Corinn ...
-
Rossi, Marcello
-
Mammana, Angela
-
Vöglein, Jonatha ...
-
show more...
-
Bernhardt, Alexa ...
-
Perrin, Richard ...
-
Jucker, Mathias
-
Preische, Oliver
-
Hofmann, Anna
-
Höglinger, Günte ...
-
Cairns, Nigel J.
-
Franklin, Erin E ...
-
Chrem, Patricio
-
Cruchaga, Carlos
-
Berman, Sarah B.
-
Chhatwal, Jasmee ...
-
Daniels, Alisha
-
Day, Gregory S.
-
Ryan, Natalie S.
-
Goate, Alison M.
-
Gordon, Brian A.
-
Huey, Edward D.
-
Ibanez, Laura
-
Karch, Celeste M ...
-
Lee, Jae Hong
-
Llibre-Guerra, J ...
-
Lopera, Francisc ...
-
Masters, Colin L ...
-
Morris, John C.
-
Noble, James M.
-
Renton, Alan E.
-
Roh, Jee Hoon
-
Frosch, Matthew ...
-
Keene, C. Dirk
-
McLean, Catriona
-
Sanchez-Valle, R ...
-
Schofield, Peter ...
-
Supnet-Bell, Cha ...
-
Xiong, Chengjie
-
Giese, Armin
-
Hansson, Oskar
-
Bateman, Randall ...
-
McDade, Eric
-
Parchi, Piero
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
- Articles in the publication
-
Alzheimer's and ...
- By the university
-
Lund University