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Multi-Infection Pat...
Multi-Infection Patterns and Co-infection Preference of 27 Human Papillomavirus Types Among 137,943 Gynecological Outpatients Across China
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- Liao, Guangdong (author)
- Sichuan University
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- Jiang, Xiyi (author)
- Hangzhou Medical College, Hangzhou
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- She, Bin (author)
- Tellgen Corporation
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- Tang, Huijuan (author)
- Hangzhou Medical College, Hangzhou
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- Wang, Zhongyong (author)
- The First Affiliated Hospital of Wenzhou Medical University, Wenzhou
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- Zhou, Hongrong (author)
- Changning Maternity and Infant Health Hospital, Shanghai
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- Ma, Yan (author)
- The First Affiliated Hospital of University of South China, Hengyang
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- Xu, Weidong (author)
- Suzhou Municipal Hospital, Suzhou
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- Xu, Hongxing (author)
- Suzhou Municipal Hospital, Suzhou
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- Chen, Wen (author)
- Peking Union Medical College
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- Ji, Jianguang (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Family Medicine and Clinical Epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Xi, Mingrong (author)
- Sichuan University
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- Chen, Tianhui (author)
- Zhejiang Cancer Hospital,Chinese Academy of Sciences
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(creator_code:org_t)
- 2020-04-07
- 2020
- English.
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In: Frontiers in Oncology. - : Frontiers Media SA. - 2234-943X. ; 10
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Abstract
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- Background: The epidemiological feature of human papillomavirus (HPV) infection is distinctive in China. We aimed to investigate the multi-infection patterns and co-infection preference of 27 HPV types among gynecological outpatients across China. Methods: Overall 137,943 gynecological outpatients were recruited from eight tertiary hospitals located in seven regions of China, between July 1st, 2014 and December 31st, 2016. The overall, region-specific, age-specific and type-specific prevalence of HPV infection were calculated, respectively. The pattern of HPV infection was also evaluated. Furthermore, rate ratio was calculated to evaluate the co-infection preference of any two HPV genotypes. Results: The overall prevalence of 27 HPVs' [17 high-risk (hr)/10 low-risk (lr)] infection was 23.5%. The age-specific HPV prevalence showed a "U-shaped" pattern. The most prevalent hrHPV genotypes were 16, 52, and 58. Multiple infections were detected in 25.8% of the HPV-positive women, in which dual infection was more prevalent. HPV 16/18 were likely to co-infected with HPV 31 but unlikely with HPV 52/58, i.e., the co-infection of HPV 16 with HPV 31 was high (3.5-fold), but low for HPV 58 (1.8-fold), and 52 (1.2-fold), while the co-infection of HPV 18 with HPV 31 was high (4.3-fold), but low for HPV 52 (1.9-fold), and 58 (1.7-fold). Conclusions: We found age-specific prevalence of HPV infection showed a "U-shaped" pattern for high and low risk HPV, suggesting the importance of screening among younger women and the necessary of detection among older women. We found a novel co-infection preference of HPV 16/18 with 31, 52, and 58, suggesting a need of developing and marketing prophylactic HPV vaccines that protect against more genotypes in China.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Liao, Guangdong
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Jiang, Xiyi
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She, Bin
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Tang, Huijuan
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Wang, Zhongyong
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Zhou, Hongrong
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Ma, Yan
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Xu, Weidong
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Xu, Hongxing
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Chen, Wen
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Ji, Jianguang
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Xi, Mingrong
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Chen, Tianhui
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Frontiers in Onc ...
- By the university
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Lund University