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Luteolin, a Potent ...
Luteolin, a Potent Anticancer Compound : From Chemistry to Cellular Interactions and Synergetic Perspectives
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- Singh Tuli, Hardeep (author)
- Maharishi Markandeshwar Engineering College
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- Rath, Prangya (author)
- Amity University
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- Chauhan, Abhishek (author)
- Amity University
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- Sak, Katrin (author)
- NGO Praeventio
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- Aggarwal, Diwakar (author)
- Maharishi Markandeshwar Engineering College
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- Choudhary, Renuka (author)
- Maharishi Markandeshwar Engineering College
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- Sharma, Ujjawal (author)
- Central University of Punjab, India
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- Vashishth, Kanupriya (author)
- Postgraduate Institute of Medical Education and Research
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- Sharma, Sheetu (author)
- Chitkara University, Punjab
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- Kumar, Manoj (author)
- Maharishi Markandeshwar University
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- Yadav, Vikas (author)
- Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine,Skåne University Hospital
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- Singh, Tejveer (author)
- University of Delhi
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- Yerer, Mukerrem Betul (author)
- Erciyes University
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- Haque, Shafiul (author)
- Jazan University
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(creator_code:org_t)
- 2022-10-31
- 2022
- English.
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In: Cancers. - : MDPI AG. - 2072-6694. ; 14:21
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Abstract
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- Increasing rates of cancer incidence and the toxicity concerns of existing chemotherapeutic agents have intensified the research to explore more alternative routes to combat tumor. Luteolin, a flavone found in numerous fruits, vegetables, and herbs, has exhibited a number of biological activities, such as anticancer and anti-inflammatory. Luteolin inhibits tumor growth by targeting cellular processes such as apoptosis, cell-cycle progression, angiogenesis and migration. Mechanistically, luteolin causes cell death by downregulating Akt, PLK-1, cyclin-B1, cyclin-A, CDC-2, CDK-2, Bcl-2, and Bcl-xL, while upregulating BAX, caspase-3, and p21. It has also been reported to inhibit STAT3 signaling by the suppression of STAT3 activation and enhanced STAT3 protein degradation in various cancer cells. Therefore, extensive studies on the anticancer properties of luteolin reveal its promising role in chemoprevention. The present review describes all the possible cellular interactions of luteolin in cancer, along with its synergistic mode of action and nanodelivery insight.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- anti-inflammation
- anti-metastasis
- apoptosis and cell cycle
- luteolin
- synergistic action
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Singh Tuli, Hard ...
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Rath, Prangya
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Chauhan, Abhishe ...
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Sak, Katrin
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Aggarwal, Diwaka ...
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Choudhary, Renuk ...
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Sharma, Ujjawal
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Vashishth, Kanup ...
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Sharma, Sheetu
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Kumar, Manoj
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Yadav, Vikas
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Singh, Tejveer
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Yerer, Mukerrem ...
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Haque, Shafiul
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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Cancers
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Lund University