id:"swepub:oai:lup.lub.lu.se:e5e49190-4e81-40df-9563-73b41190953b"
Search: id:"swepub:oai:lup.lub.lu.se:e5e49190-4e81-40df-9563-73b41190953b" > Genome-wide associa...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Smith, GustavLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine (author)
Genome-wide association studies of late-onset cardiovascular disease.
- Article/chapterEnglish2015
Publisher, publication year, extent ...
- Elsevier BV,2015
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:e5e49190-4e81-40df-9563-73b41190953b
- https://lup.lub.lu.se/record/5341972URI
- https://doi.org/10.1016/j.yjmcc.2015.04.004DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Human genetics is a powerful tool for discovering causal mediators of human disease and physiology. Cardiovascular diseases with late onset in the lifecourse have historically not been considered genetic diseases, but in recent years the contribution of a heritable factor has been established. More importantly, over the last decade genome-wide association studies (GWASs) have identified many loci associated with late-onset cardiovascular diseases including coronary artery disease, carotid artery disease, ischemic stroke, aortic aneurysm, peripheral vascular disease, atrial fibrillation, valvular disease and correlates of vascular and myocardial function. Here we review findings from GWASs considered statistically robust with regard to multiple testing (p<5×10(-8)) for late-onset cardiovascular diseases and traits. Although for only a handful of the 92 genetic loci described here have the mechanisms underlying disease association been established, new and previously unsuspected pathways have been implicated for several conditions. Examples include a role for NO signaling in myocardial repolarization and sudden cardiac death and a role for the protein sortilin in lipid metabolism and coronary artery disease. Genetic loci with multiple trait associations have also provided novel biological insights. For example, of the 46 genetic loci associated with coronary artery disease, only 16 are also associated with conventional risk factors for cardiovascular disease whereas the remaining two thirds may reflect novel pathways. Much work remains to functionally characterize genetic loci and for clinical utility, but accruing insights into the biological basis of cardiovascular aging in human populations promise to point to novel therapeutic and preventive strategies. This article is part of a Special Issue entitled 'SI:CV Aging'.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
- Newton-Cheh, Christopher (author)
- KardiologiSektion II (creator_code:org_t)
Related titles
- In:Journal of Molecular and Cellular Cardiology: Elsevier BV83:Apr 11, s. 131-1411095-85840022-2828
Internet link
Find in a library
- Journal of Molecular and Cellular Cardiology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Smith, Gustav
- Newton-Cheh, Chr ...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cardiac and Card ...
- Articles in the publication
- Journal of Molec ...
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
