Association between vitamin D receptor gene polymorphisms, falls, balance and muscle power : results from two independent studies (APOSS and OPUS)

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Barr, RUniversity of Aberdeen (författare)

Association between vitamin D receptor gene polymorphisms, falls, balance and muscle power : results from two independent studies (APOSS and OPUS)

Artikel/kapitelEngelska2010

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2009-07-24
Springer Science and Business Media LLC,2010

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LIBRIS-ID:oai:lup.lub.lu.se:e64eef52-96bc-4e42-b175-9416db2f7577
https://lup.lub.lu.se/record/e64eef52-96bc-4e42-b175-9416db2f7577URI
https://doi.org/10.1007/s00198-009-1019-6DOI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:ref swepub-contenttype

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SUMMARY: Fall prevention is a key strategy for reducing osteoporotic fractures. We investigated the association between vitamin D receptor (VDR) polymorphisms and reported falls in postmenopausal women. Bsm1 polymorphisms were associated with falls, balance and muscle power measurements. These results may explain some of the excess fracture risk associated with VDR in some studies.INTRODUCTION: Fall prevention is a key strategy for reducing osteoporotic fractures. It has been suggested that vitamin D supplementation may reduce the incidence of falls by reducing body sway and increasing muscle power. The vitamin D receptor gene is a well-studied candidate gene for osteoporosis. We investigated the association between VDR polymorphisms and reported falls in postmenopausal women.METHODS: Falls data were collected in two separate population cohorts. Five polymorphisms of the VDR gene were analysed (Cdx-2, Fok-1, BsmI, Taq1 and Apa1) in the Aberdeen Prospective Osteoporosis Screening Study (APOSS) cohort. Results found in APOSS were then validated in an independent cohort--the Osteoporosis and Ultrasound (OPUS) study (Bsm1 and Fok1 only), where muscle power and balance were also measured.RESULTS: Carriers of the 'B' allele (Bsm1) showed an increased risk for falls. In APOSS, this was statistically significant for visit 3 multiple falls (p = 0.047) and for recurrent falls (p = 0.043). Similar results were found in OPUS for visit 1 falls (p = 0.025) and visit 1 multiple falls (p = 0.015). Bsm1 polymorphisms were also associated with balance and muscle power measurements.CONCLUSIONS: In conclusion, these results demonstrate an association between the Bsm1 polymorphism and risk of falling that may explain some of the excess fracture risk associated with VDR in some studies.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Ortopedi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Orthopaedics hsv//eng
Accidental Falls
Aged
Aged, 80 and over
Cohort Studies
Female
Gene Frequency
Genetic Predisposition to Disease
Humans
Middle Aged
Muscle Strength
Parathyroid Hormone
Polymorphism, Genetic
Postmenopause
Postural Balance
Receptors, Calcitriol
Risk Assessment
Vitamin D

Biuppslag (personer, institutioner, konferenser, titlar ...)

Macdonald, HUniversity of Aberdeen (författare)
Stewart, AUniversity of Aberdeen (författare)
McGuigan, FLund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,University of Aberdeen(Swepub:lu)med-fam (författare)
Rogers, AUniversity of Sheffield (författare)
Eastell, RUniversity of Sheffield (författare)
Felsenberg, DHumboldt University of Berlin (författare)
Glüer, CUniversity Medical Center Schleswig-Holstein (författare)
Roux, CParis Descartes University (författare)
Reid, D MUniversity of Aberdeen (författare)
University of AberdeenOrtopedi - klinisk och molekylär osteoporosforskning (creator_code:org_t)

Sammanhörande titlar

Ingår i:Osteoporosis International: Springer Science and Business Media LLC21:3, s. 66-4571433-29650937-941X

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Av författaren/redakt...: Barr, R; Macdonald, H; Stewart, A; McGuigan, F; Rogers, A; Eastell, R; visa fler...; Felsenberg, D; Glüer, C; Roux, C; Reid, D M; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Ortopedi

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Av lärosätet: Lunds universitet

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