Structural Basis for Glycerol Efflux and Selectivity of Human Aquaporin 7

• AQP7 is an important glycerol channel in human adipocytes, and its dysfunction is linked to metabolic disorders. The high-resolution X-ray structures of AQP7 unravels the molecular details of how glycerol travels through the channel and provide a structural basis for development of small-molecule drugs for targeting AQP7.

Subject headings

NATURVETENSKAP  -- Biologi -- Strukturbiologi (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences -- Structural Biology (hsv//eng)

Keyword

adipocyte

AQP7

aquaglyceroporin

aquaporin 7

atomistic MD simulations

glycerol channel

water

X-ray structure

Publication and Content Type

art (subject category)

ref (subject category)