SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Ordovas Jose M.)
 

Sökning: WFRF:(Ordovas Jose M.) > (2020-2023) > Meal-induced inflam...

  • Mazidi, MohsenKing's College London (författare)

Meal-induced inflammation : postprandial insights from the Personalised REsponses to DIetary Composition Trial (PREDICT) study in 1000 participants

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2021
  • 11 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:e6e1a2fd-234a-4add-996c-a59204681abd
  • https://lup.lub.lu.se/record/e6e1a2fd-234a-4add-996c-a59204681abdURI
  • https://doi.org/10.1093/ajcn/nqab132DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • BACKGROUND: Meal-induced metabolic changes trigger an acute inflammatory response, contributing to chronic inflammation and associated diseases. OBJECTIVES: We aimed to characterize variability in postprandial inflammatory responses using traditional (IL-6) and novel [glycoprotein acetylation (GlycA)] biomarkers of inflammation and dissect their biological determinants with a focus on postprandial glycemia and lipemia. METHODS: Postprandial (0-6 h) glucose, triglyceride (TG), IL-6, and GlycA responses were measured at multiple intervals after sequential mixed-nutrient meals (0 h and 4 h) in 1002 healthy adults aged 18-65 y from the PREDICT (Personalised REsponses to DIetary Composition Trial) 1 study, a single-arm dietary intervention study. Measures of habitual diet, blood biochemistry, gut microbiome composition, and visceral fat mass (VFM) were also collected. RESULTS: The postprandial changes in GlycA and IL-6 concentrations were highly variable between individuals. Participants eliciting an increase in GlycA and IL-6 (60% and 94% of the total participants, respectively) had mean 6-h increases of 11% and 190%, respectively. Peak postprandial TG and glucose concentrations were significantly associated with 6-h GlycA (r = 0.83 and r = 0.24, respectively; both P < 0.001) but not with 6-h IL-6 (both P > 0.26). A random forest model revealed the maximum TG concentration was the strongest postprandial TG predictor of postprandial GlycA and structural equation modeling revealed that VFM and fasting TG were most strongly associated with fasting and postprandial GlycA. Network Mendelian randomization demonstrated a causal link between VFM and fasting GlycA, mediated (28%) by fasting TG. Individuals eliciting enhanced GlycA responses had higher predicted cardiovascular disease risk (using the atherosclerotic disease risk score) than the rest of the cohort. CONCLUSIONS: The variable postprandial increases in GlycA and their associations with TG metabolism highlight the importance of modulating TG in concert with obesity to reduce GlycA and associated low-grade inflammation-related diseases.This trial was registered at clinicaltrials.gov as NCT03479866.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Valdes, Ana M.Nottingham Biomedical Research Centre (BRC),University of Nottingham (författare)
  • Ordovas, Jose M.Tufts University (författare)
  • Hall, Wendy L.King's College London (författare)
  • Pujol, Joan C.Zoe Global Limited (författare)
  • Wolf, JonathanZoe Global Limited (författare)
  • Hadjigeorgiou, GeorgeZoe Global Limited (författare)
  • Segata, NicolaUniversity of Trento (författare)
  • Sattar, NaveedGlasgow Royal Infirmary (författare)
  • Koivula, RobertUniversity of Oxford(Swepub:lu)med-rkl (författare)
  • Spector, Tim D.King's College London (författare)
  • Franks, Paul W.Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,King's College London,Harvard University(Swepub:lu)med-plf (författare)
  • Berry, Sarah E.King's College London (författare)
  • King's College LondonNottingham Biomedical Research Centre (BRC) (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:The American journal of clinical nutrition: Elsevier BV114:3, s. 1028-10381938-32070002-9165

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy