Increased endothelial expression of HLA-DQ and interleukin 1alpha in extra-articular rheumatoid arthritis. Results from immunohistochemical studies of skeletal muscle

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Turesson, C (author)

Increased endothelial expression of HLA-DQ and interleukin 1alpha in extra-articular rheumatoid arthritis. Results from immunohistochemical studies of skeletal muscle

Article/chapterEnglish2001

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Oxford University Press (OUP),2001

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LIBRIS-ID:oai:lup.lub.lu.se:e7e30f9a-2e64-48ce-add1-2184b9417fc4
https://lup.lub.lu.se/record/1121364URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:1930237URI
https://doi.org/10.1093/rheumatology/40.12.1346DOI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

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OBJECTIVE: To investigate markers of endothelial activation in muscle biopsies from rheumatoid arthritis (RA) patients with and without extra-articular manifestations (ExRA). PATIENTS AND METHODS: Nine consecutive ExRA patients were compared with nine RA controls without ExRA, matched for age, sex and duration of RA. Muscle biopsies were obtained from the lateral vastus or anterior tibial muscle. Macrophage and lymphocyte CD markers, HLA molecules, cytokines and adhesion molecules were investigated using immunohistochemistry, and stainings were evaluated using computer image analysis and conventional microscopy. Serum concentrations of soluble adhesion molecules, tumour necrosis factor alpha (TNF-alpha) and rheumatoid factor (RF) were determined using immunoassays. RESULTS: The number of HLA-DQ-positive capillaries (P=0.039) and the expression of interleukin 1alpha (IL-1alpha) in endothelial cells (mean pairwise difference 0.26%; 95% confidence interval 0-0.52) were increased in ExRA patients compared with non-ExRA controls. There were no signs of inflammatory cell infiltrates or fibre degeneration. Serum levels of TNF-alpha, the soluble form of intercellular adhesion molecule 1, the soluble form of vascular cell adhesion molecule 1 and IgM RF were increased in the ExRA group. CONCLUSION: The increased expression of HLA-DQ and IL-1alpha may indicate systemic endothelial activation in extra-articular RA, which could be of importance for cardiovascular comorbidity and mortality in such patients.

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Englund, P (author)
Jacobsson, L T (author)
Sturfelt, GunnarLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-gst (author)
Truedsson, LennartLund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)mmb-ltr (author)
Nennesmo, IKarolinska Institutet (author)
Lundberg, I EKarolinska Institutet (author)
Reumatologi och molekylär skelettbiologiSektion III (creator_code:org_t)

Related titles

In:Rheumatology: Oxford University Press (OUP)40:12, s. 1346-13541462-0332
In:Rheumatology (Oxford, England): Oxford University Press (OUP)40:12, s. 1346-13541462-03241460-2172

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By the author/editor: Turesson, C; Englund, P; Jacobsson, L T; Sturfelt, Gunnar; Truedsson, Lenna ...; Nennesmo, I; show more...; Lundberg, I E; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Rheumatology and ...

Articles in the publication: Rheumatology; Rheumatology (Ox ...

By the university: Lund University; Karolinska Institutet

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