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Genome-wide associa...
Genome-wide association meta-analysis of single-nucleotide polymorphisms and symptomatic venous thromboembolism during therapy for acute lymphoblastic leukemia and lymphoma in caucasian children
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- Mateos, Marion K. (author)
- University of New South Wales,Sydney Children's Hospital
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- Tulstrup, Morten (author)
- Copenhagen University Hospital
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- Quinn, Michael C.J. (author)
- QIMR Berghofer Medical Research Institute
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- Tuckuviene, Ruta (author)
- Aalborg University Hospital
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- Marshall, Glenn M. (author)
- University of New South Wales,Sydney Children's Hospital
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- Gupta, Ramneek (author)
- Technical University of Denmark
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- Mayoh, Chelsea (author)
- University of New South Wales
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- Wolthers, Benjamin O. (author)
- Copenhagen University Hospital
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- Barbaro, Pasquale M. (author)
- University of Sydney
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- Ruud, Ellen (author)
- Oslo university hospital,University of Oslo
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- Sutton, Rosemary (author)
- University of New South Wales
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- Huttunen, Pasi (author)
- Helsinki University Children's Hospital
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- Revesz, Tamas (author)
- Royal Adelaide Hospital
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- Trakymiene, Sonata S. (author)
- Vilnius University
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- Barbaric, Draga (author)
- Sydney Children's Hospital
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- Tedgård, Ulf (author)
- Lund University,Lunds universitet,Pediatrisk hematologi,Forskargrupper vid Lunds universitet,Paediatric Haematology Research Unit,Lund University Research Groups,Skåne University Hospital
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- Giles, Jodie E. (author)
- University of New South Wales
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- Alvaro, Frank (author)
- University of Newcastle
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- Jonsson, Olafur G. (author)
- National University Hospital of Iceland
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- Mechinaud, Françoise (author)
- Royal Children's Hospital, Melbourne,Hôpital universitaire Robert-Debré
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- Saks, Kadri (author)
- Tallinn Children's Hospital
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- Catchpoole, Daniel (author)
- Children's Hospital At Westmead
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- Kotecha, Rishi S. (author)
- Curtin University
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- Dalla-Pozza, Luciano (author)
- Children's Hospital At Westmead
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- Chenevix-Trench, Georgia (author)
- QIMR Berghofer Medical Research Institute
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- Trahair, Toby N. (author)
- University of New South Wales,Sydney Children's Hospital
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- Macgregor, Stuart (author)
- QIMR Berghofer Medical Research Institute
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- Schmiegelow, Kjeld (author)
- University of Copenhagen,Copenhagen University Hospital
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(creator_code:org_t)
- 2020-05-19
- 2020
- English.
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In: Cancers. - : MDPI AG. - 2072-6694. ; 12:5
- Related links:
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http://dx.doi.org/10... (free)
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https://www.mdpi.com...
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Subject headings
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- Symptomatic venous thromboembolism (VTE) occurs in five percent of children treated for acute lymphoblastic leukemia (ALL), but whether a genetic predisposition exists across different ALL treatment regimens has not been well studied. Methods: We undertook a genome-wide association study (GWAS) meta-analysis for VTE in consecutively treated children in the Nordic/Baltic acute lymphoblastic leukemia 2008 (ALL2008) cohort and the Australian Evaluation of Risk of ALL Treatment-Related Side-Effects (ERASE) cohort. A total of 92 cases and 1481 controls of European ancestry were included. Results: No SNPs reached genome-wide significance (p < 5 × 10−8) in either cohort. Among the top 34 single-nucleotide polymorphisms (SNPs) (p < 1 × 10−6), two loci had concordant effects in both cohorts: ALOX15B (rs1804772) (MAF: 1%; p = 3.95 × 10−7) that influences arachidonic acid metabolism and thus platelet aggregation, and KALRN (rs570684) (MAF: 1%; p = 4.34 × 10−7) that has been previously associated with risk of ischemic stroke, atherosclerosis, and early-onset coronary artery disease. Conclusion: This represents the largest GWAS meta-analysis conducted to date associating SNPs to VTE in children and adolescents treated on childhood ALL protocols. Validation of these findings is needed and may then lead to patient stratification for VTE preventive interventions. As VTE hemostasis involves multiple pathways, a more powerful GWAS is needed to detect combination of variants associated with VTE.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- Acute lymphoblastic leukemia
- Child
- Genome-wide association study
- Single-nucleotide polymorphism
- Venous thromboembolism
Publication and Content Type
- art (subject category)
- ref (subject category)
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Cancers
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- By the author/editor
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Mateos, Marion K ...
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Tulstrup, Morten
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Quinn, Michael C ...
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Tuckuviene, Ruta
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Marshall, Glenn ...
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Gupta, Ramneek
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show more...
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Mayoh, Chelsea
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Wolthers, Benjam ...
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Barbaro, Pasqual ...
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Ruud, Ellen
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Sutton, Rosemary
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Huttunen, Pasi
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Revesz, Tamas
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Trakymiene, Sona ...
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Barbaric, Draga
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Tedgård, Ulf
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Giles, Jodie E.
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Alvaro, Frank
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Jonsson, Olafur ...
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Mechinaud, Franç ...
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Saks, Kadri
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Catchpoole, Dani ...
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Kotecha, Rishi S ...
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Dalla-Pozza, Luc ...
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Chenevix-Trench, ...
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Trahair, Toby N.
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Macgregor, Stuar ...
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Schmiegelow, Kje ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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Cancers
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Lund University