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Repeatability of Ep...
Repeatability of Epithelium Thickness Measured by an AS-OCT in Different Grades of Keratoconus and Compared to AS-OCT/Placido Topography
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- Wang, Yiran (författare)
- Fudan University
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- Ning, Rui (författare)
- Fudan University
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- Li, Kexin (författare)
- Fudan University
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- Xu, Huilin (författare)
- Fudan University
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- Li, Yue (författare)
- Fudan University
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- Yang, Yizhou (författare)
- Fudan University
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- Gustafsson, Ingemar (författare)
- Lund University,Lunds universitet,Klinisk forskning inom hornhinnesjukdomar,Forskargrupper vid Lunds universitet,Clinical research in corneal disease and disorders,Lund University Research Groups
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- Zhou, Xingtao (författare)
- Fudan University
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- Qu, Xiaomei (författare)
- Fudan University
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- Huang, Jinhai (författare)
- Fudan University
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(creator_code:org_t)
- 2024
- 2024
- Engelska 11 s.
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Ingår i: American Journal of Ophthalmology. - 0002-9394. ; 265, s. 213-223
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- PURPOSE: To compare agreement of corneal epithelium thickness (ET) between AS-OCT system (RTVue, Optovue) and AS-OCT/Placido topographer (MS-39, CSO) in eyes with different stages of keratoconus (KC), and to assess the repeatability of RTVue AS-OCT. DESIGN: Prospective reliability analysis. METHODS: KC eyes were classified into forme fruste KC (FFKC), mild, moderate, and severe KC. Agreement was evaluated with Bland–Altman plots and 95% limits of agreement (LoA). The repeatability of RTVue was assessed via within-subject standard deviation (Sw), test–retest variability (TRT), coefficient of variation (CoV), and intraclass correlation coefficient (ICC). RESULTS: A total of 119 KC eyes were enrolled, with 21 being FFKC, 26 mild, 39 moderate, and 34 severe. The 95% LoA ranged between −5.9 and 4.8 µm for center epithelium thickness (CET), between −5.7 and 8.2 µm for thinnest epithelium thickness (TET). At 1-mm measuring points, the 95% LoA of superior, inferior, nasal, and temporal were −4.2 to 4.7 µm, −5.2 to 6.0 µm, −7.9 to 10.2 µm, and −11.2 to 6.0 µm. At 3-mm measuring points, the corresponding values were −2.8 to 9.3 µm, −2.0 to 13.0 µm, −4.6 to 9.6 µm, and −6.3 to 9.7 µm, indicating that the 2 instruments were not interchangeable without adjustment. Despite that the repeatability of RTVue measurements in KC patients were acceptable, repeatability decreased gradually with the peripheralization of the measurement points. CONCLUSIONS: The 2 OCT-based devices, RTVue and MS-39, do not provide interchangeable measurements of epithelium thickness in KC patients. Repeatability decreases in cases of more severe KC, emphasizing the importance of grading before clinical examination to avoid diagnostic errors.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
Nyckelord
- Corneal epithelium thickness
- keratoconus
- Optical biometry
- optical coherence tomography
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Wang, Yiran
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Ning, Rui
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Li, Kexin
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Xu, Huilin
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Li, Yue
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Yang, Yizhou
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visa fler...
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Gustafsson, Inge ...
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Zhou, Xingtao
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Qu, Xiaomei
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Huang, Jinhai
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Oftalmologi
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American Journal ...
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Lunds universitet