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Treatment of spasti...
Treatment of spasticity in children and adolescents with cerebral palsy in Northern Europe : a CP-North registry study
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- Hägglund, Gunnar (författare)
- Lund University,Lunds universitet,CPUP - barnortopedisk forskningsgrupp,Forskargrupper vid Lunds universitet,CPUP - Children's Orthopedics Group,Lund University Research Groups,Skåne University Hospital
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- Hollung, Sandra Julsen (författare)
- Vestfold Hospital
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- Ahonen, Matti (författare)
- University of Helsinki
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- Andersen, Guro L (författare)
- Vestfold Hospital
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- Eggertsdóttir, Guðbjörg (författare)
- SLF's Rehabilitation Center-Æfingastöðin
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- Gaston, Mark S (författare)
- Royal Hospital for Sick Children, Edinburgh
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- Jahnsen, Reidun (författare)
- Oslo university hospital
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- Jeglinsky-Kankainen, Ira (författare)
- Arcada University of Applied Sciences
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- Nordbye-Nielsen, Kirsten (författare)
- Aarhus University
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- Tresoldi, Ilaria (författare)
- Aarhus University Hospital,Aarhus University
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- Alriksson-Schmidt, Ann I (författare)
- Lund University,Lunds universitet,CPUP - barnortopedisk forskningsgrupp,Forskargrupper vid Lunds universitet,Att leva med funktionsnedsättning: Forskning ur ett folkhälsoperspektiv,CPUP - Children's Orthopedics Group,Lund University Research Groups,Living with a Disability: Research from a Public Health Perspective,Skåne University Hospital
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(creator_code:org_t)
- 2021-07-12
- 2021
- Engelska.
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Ingår i: BMC Neurology. - : Springer Science and Business Media LLC. - 1471-2377. ; 21:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://bmcneurol.bi...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Spasticity is present in more than 80% of the population with cerebral palsy (CP). The aim of this study was to describe and compare the use of three spasticity reducing methods; Botulinum toxin-A therapy (BTX-A), Selective dorsal rhizotomy (SDR) and Intrathecal baclofen therapy (ITB) among children and adolescents with CP in six northern European countries.METHODS: This registry-based study included population-based data in children and adolescents with CP born 2002 to 2017 and recorded in the follow-up programs for CP in Sweden, Norway, Denmark, Iceland and Scotland, and a defined cohort in Finland.RESULTS: A total of 8,817 individuals were included. The proportion of individuals treated with SDR and ITB was significantly different between the countries. SDR treatment ranged from 0% ( Finland and Iceland) to 3.4% (Scotland) and ITB treatment from 2.2% (Sweden) to 3.7% (Denmark and Scotland). BTX-A treatment in the lower extremities reported 2017-2018 ranged from 8.6% in Denmark to 20% in Norway (p < 0.01). Mean age for undergoing SDR ranged from 4.5 years in Norway to 7.3 years in Denmark (p < 0.01). Mean age at ITB surgery ranged from 6.3 years in Norway to 10.1 years in Finland (p < 0.01). Mean age for BTX-A treatment ranged from 7.1 years in Denmark to 10.3 years in Iceland (p < 0.01). Treatment with SDR was most common in Gross Motor Function Classification System (GMFCS) level III, ITB in level V, and BTX-A in level I. The most common muscle treated with BTX-A was the calf muscle, with the highest proportion in GMFCS level I. BTX-A treatment of hamstring and hip muscles was most common in GMFCS levels IV-V in all countries.CONCLUSION: There were statistically significant differences between countries regarding the proportion of children and adolescents with CP treated with the three spasticity reducing methods, mean age for treatment and treatment related to GMFCS level. This is likely due to differences in the availability of these treatment methods and/or differences in preferences of treatment methods among professionals and possibly patients across countries.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Adolescent
- Baclofen/administration & dosage
- Botulinum Toxins, Type A/administration & dosage
- Cerebral Palsy/diagnosis
- Child
- Child, Preschool
- Cohort Studies
- Europe/epidemiology
- Humans
- Injections, Spinal/methods
- Male
- Muscle Relaxants, Central/administration & dosage
- Muscle Spasticity/diagnosis
- Muscle, Skeletal/drug effects
- Registries
- Rhizotomy/methods
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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