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Genetic predictors of lifelong medication-use patterns in cardiometabolic diseases
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- Kiiskinen, Tuomo (author)
- University of Helsinki,Massachusetts Institute of Technology,Finnish National Institute for Health and Welfare
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- Helkkula, Pyry (author)
- University of Helsinki
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Krebs, Kristi (author)
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- Karjalainen, Juha (author)
- University of Helsinki,Massachusetts General Hospital,Massachusetts Institute of Technology
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- Saarentaus, Elmo (author)
- University of Helsinki
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- Mars, Nina (author)
- University of Helsinki
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- Lehisto, Arto (author)
- University of Helsinki
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- Zhou, Wei (author)
- Massachusetts Institute of Technology
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- Cordioli, Mattia (author)
- University of Helsinki
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- Jukarainen, Sakari (author)
- University of Helsinki
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- Rämö, Joel T. (author)
- University of Helsinki
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- Mehtonen, Juha (author)
- University of Helsinki
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- Veerapen, Kumar (author)
- Massachusetts Institute of Technology
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- Räsänen, Markus (author)
- University of Helsinki
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- Ruotsalainen, Sanni (author)
- University of Helsinki
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- Maasha, Mutaamba (author)
- Massachusetts Institute of Technology
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- Niiranen, Teemu (author)
- University of Turku,Turku University Hospital,Finnish National Institute for Health and Welfare
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- Tuomi, Tiinamaija (author)
- Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups,Folkhälsan Research Center,Helsinki University Central Hospital,University of Helsinki
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- Salomaa, Veikko (author)
- Finnish National Institute for Health and Welfare
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- Kurki, Mitja (author)
- Massachusetts General Hospital,University of Helsinki,Massachusetts Institute of Technology
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- Pirinen, Matti (author)
- University of Helsinki
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- Palotie, Aarno (author)
- University of Helsinki,Broad Institute,Massachusetts General Hospital
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- Daly, Mark (author)
- Massachusetts General Hospital,University of Helsinki,Broad Institute
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- Ganna, Andrea (author)
- Massachusetts Institute of Technology,University of Helsinki
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- Havulinna, Aki S. (author)
- University of Helsinki,Finnish National Institute for Health and Welfare
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Milani, Lili (author)
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- Ripatti, Samuli (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Harvard University,University of Helsinki
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(creator_code:org_t)
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- 2023-01-18
- 2023
- English 10 s.
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In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 29:1, s. 209-218
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http://dx.doi.org/10... (free)
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Abstract
Subject headings
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- Little is known about the genetic determinants of medication use in preventing cardiometabolic diseases. Using the Finnish nationwide drug purchase registry with follow-up since 1995, we performed genome-wide association analyses of longitudinal patterns of medication use in hyperlipidemia, hypertension and type 2 diabetes in up to 193,933 individuals (55% women) in the FinnGen study. In meta-analyses of up to 567,671 individuals combining FinnGen with the Estonian Biobank and the UK Biobank, we discovered 333 independent loci (P < 5 × 10–9) associated with medication use. Fine-mapping revealed 494 95% credible sets associated with the total number of medication purchases, changes in medication combinations or treatment discontinuation, including 46 credible sets in 40 loci not associated with the underlying treatment targets. The polygenic risk scores (PRS) for cardiometabolic risk factors were strongly associated with the medication-use behavior. A medication-use enhanced multitrait PRS for coronary artery disease matched the performance of a risk factor-based multitrait coronary artery disease PRS in an independent sample (UK Biobank, n = 343,676). In summary, we demonstrate medication-based strategies for identifying cardiometabolic risk loci and provide genome-wide tools for preventing cardiovascular diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Kiiskinen, Tuomo
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Helkkula, Pyry
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Krebs, Kristi
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Karjalainen, Juh ...
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Saarentaus, Elmo
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Mars, Nina
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show more...
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Lehisto, Arto
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Zhou, Wei
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Cordioli, Mattia
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Jukarainen, Saka ...
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Rämö, Joel T.
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Mehtonen, Juha
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Veerapen, Kumar
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Räsänen, Markus
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Ruotsalainen, Sa ...
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Maasha, Mutaamba
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Niiranen, Teemu
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Tuomi, Tiinamaij ...
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Salomaa, Veikko
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Kurki, Mitja
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Pirinen, Matti
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Palotie, Aarno
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Daly, Mark
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Ganna, Andrea
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Havulinna, Aki S ...
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Milani, Lili
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Ripatti, Samuli
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Nature Medicine
- By the university
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Lund University