SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Mehtonen Juha)
 

Search: WFRF:(Mehtonen Juha) > Genetic predictors ...

  • Kiiskinen, TuomoUniversity of Helsinki,Massachusetts Institute of Technology,Finnish National Institute for Health and Welfare (author)

Genetic predictors of lifelong medication-use patterns in cardiometabolic diseases

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2023-01-18
  • Springer Science and Business Media LLC,2023
  • 10 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:e8c2f5a4-2725-4c7f-9e89-ea8af981811d
  • https://lup.lub.lu.se/record/e8c2f5a4-2725-4c7f-9e89-ea8af981811dURI
  • https://doi.org/10.1038/s41591-022-02122-5DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Little is known about the genetic determinants of medication use in preventing cardiometabolic diseases. Using the Finnish nationwide drug purchase registry with follow-up since 1995, we performed genome-wide association analyses of longitudinal patterns of medication use in hyperlipidemia, hypertension and type 2 diabetes in up to 193,933 individuals (55% women) in the FinnGen study. In meta-analyses of up to 567,671 individuals combining FinnGen with the Estonian Biobank and the UK Biobank, we discovered 333 independent loci (P < 5 × 10–9) associated with medication use. Fine-mapping revealed 494 95% credible sets associated with the total number of medication purchases, changes in medication combinations or treatment discontinuation, including 46 credible sets in 40 loci not associated with the underlying treatment targets. The polygenic risk scores (PRS) for cardiometabolic risk factors were strongly associated with the medication-use behavior. A medication-use enhanced multitrait PRS for coronary artery disease matched the performance of a risk factor-based multitrait coronary artery disease PRS in an independent sample (UK Biobank, n = 343,676). In summary, we demonstrate medication-based strategies for identifying cardiometabolic risk loci and provide genome-wide tools for preventing cardiovascular diseases.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Helkkula, PyryUniversity of Helsinki (author)
  • Krebs, Kristi (author)
  • Karjalainen, JuhaUniversity of Helsinki,Massachusetts General Hospital,Massachusetts Institute of Technology (author)
  • Saarentaus, ElmoUniversity of Helsinki (author)
  • Mars, NinaUniversity of Helsinki (author)
  • Lehisto, ArtoUniversity of Helsinki (author)
  • Zhou, WeiMassachusetts Institute of Technology (author)
  • Cordioli, MattiaUniversity of Helsinki (author)
  • Jukarainen, SakariUniversity of Helsinki (author)
  • Rämö, Joel T.University of Helsinki (author)
  • Mehtonen, JuhaUniversity of Helsinki (author)
  • Veerapen, KumarMassachusetts Institute of Technology (author)
  • Räsänen, MarkusUniversity of Helsinki (author)
  • Ruotsalainen, SanniUniversity of Helsinki (author)
  • Maasha, MutaambaMassachusetts Institute of Technology (author)
  • Niiranen, TeemuUniversity of Turku,Turku University Hospital,Finnish National Institute for Health and Welfare (author)
  • Tuomi, TiinamaijaLund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups,Folkhälsan Research Center,Helsinki University Central Hospital,University of Helsinki(Swepub:lu)ti8736tu (author)
  • Salomaa, VeikkoFinnish National Institute for Health and Welfare (author)
  • Kurki, MitjaMassachusetts General Hospital,University of Helsinki,Massachusetts Institute of Technology (author)
  • Pirinen, MattiUniversity of Helsinki (author)
  • Palotie, AarnoUniversity of Helsinki,Broad Institute,Massachusetts General Hospital (author)
  • Daly, MarkMassachusetts General Hospital,University of Helsinki,Broad Institute (author)
  • Ganna, AndreaMassachusetts Institute of Technology,University of Helsinki (author)
  • Havulinna, Aki S.University of Helsinki,Finnish National Institute for Health and Welfare (author)
  • Milani, Lili (author)
  • Ripatti, SamuliLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Harvard University,University of Helsinki(Swepub:lu)med-sur (author)
  • University of HelsinkiMassachusetts Institute of Technology (creator_code:org_t)
  • FinnGen

Related titles

  • In:Nature Medicine: Springer Science and Business Media LLC29:1, s. 209-2181078-89561546-170X

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view