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  • Hagstrand Aldman, MalinLund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Luftvägar, patogener, immunförsvar,Forskargrupper vid Lunds universitet,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Airways, pathogens, innate immunity,Lund University Research Groups,Skåne University Hospital (author)

Biofilm formation is associated with poor outcome in prosthetic joint infections caused by Staphylococcus lugdunensis

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2023-02-17
  • Informa UK Limited,2023

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:e921df32-7e19-4256-b22a-e4d5ba8383e5
  • https://lup.lub.lu.se/record/e921df32-7e19-4256-b22a-e4d5ba8383e5URI
  • https://doi.org/10.1080/23744235.2023.2180534DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: Staphylococcus lugdunensis has been described as a pathogen of increasing importance in prosthetic joint infections (PJI). Our aim was to describe the clinical presentation of PJI caused by S. lugdunensis, and to correlate the biofilm-forming ability of the bacterial isolates to clinical outcome. Method: S. lugdunensis isolates from PJI episodes during 2015–2019 were included and analysed for biofilm formation using a microtiter plate assay. Medical records from the corresponding patients were reviewed. Results: We identified 36 patients with PJI caused by S. lugdunensis during the study period. Early postoperative PJIs were most frequent (n = 20, 56%). Surgical intervention was performed in a majority of the patients (n = 33, 92%), and the dominating type of antibiotic treatment was a combination of rifampicin and ciprofloxacin (n = 27, 75%). The treatment success-rate was 81% (n = 29). All isolates causing PJI were able to form biofilm in vitro. Biofilm formation was significantly stronger in isolates causing relapsing vs non-relapsing PJI (mean OD550 3.1 ± 0.23 vs 1.14 ± 0.73 p =.001) and strong biofilm formation was also associated with late acute hematogenic PJI (mean OD550 1.8 ± 0.93 vs. 0.93 ± 0.81, p =.01). Conclusion: Strong biofilm production in S. lugdunensis isolates was associated with relapse in PJI.

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  • Thompson, OlofLund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)med-olt (author)
  • Påhlman, Lisa I.Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Luftvägar, patogener, immunförsvar,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Airways, pathogens, innate immunity,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Skåne University Hospital(Swepub:lu)medk-lpa (author)
  • InfektionsmedicinSektion III (creator_code:org_t)

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  • In:Infectious Diseases: Informa UK Limited55:5, s. 328-3322374-42352374-4243

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