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  • Pedro, Joana ReisUniversity of Coimbra (author)

Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • Elsevier BV,2020
  • 10 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:e9b477ee-f150-47bf-80aa-e6e11be1687a
  • https://lup.lub.lu.se/record/e9b477ee-f150-47bf-80aa-e6e11be1687aURI
  • https://doi.org/10.1016/j.brainresbull.2020.05.004DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Here we aimed to unify some previous controversial reports on changes in both cannabinoid CB1 receptor (CB1R) expression and glucose metabolism in the forebrain of rodent models of diabetes. We determined how glucose metabolism and its modulation by CB1R ligands evolve in the frontal cortex of young adult male Wistar rats, in the first 8 weeks of streptozotocin-induced type-1 diabetes (T1D). We report that frontocortical CB1R protein density was biphasically altered in the first month of T1D, which was accompanied with a reduction of resting glucose uptake ex vivo in acute frontocortical slices that was normalized after eight weeks in T1D. This early reduction of glucose uptake in slices was also restored by ex vivo treatment with both the non-selective CB1R agonists, WIN55212−2 (500 nM) and the CB1R-selective agonist, ACEA (3 μM) while it was exacerbated by the CB1R-selective antagonist, O-2050 (500 nM). These results suggest a gain-of-function for the cerebrocortical CB1Rs in the control of glucose uptake in diabetes. Although insulin and IGF-1 receptor protein densities remained unaffected, phosphorylated GSKα and GSKβ levels showed different profiles 2 and 8 weeks after T1D induction in the frontal cortex. Altogether, the biphasic response in frontocortical CB1R density within a month after T1D induction resolves previous controversial reports on forebrain CB1R levels in T1D rodent models. Furthermore, this study also hints that cannabinoids may be useful to alleviate impaired glucoregulation in the diabetic cortex.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Moura, Liane I.F.University of Coimbra (author)
  • Valério-Fernandes, ÂngelaUniversity of Coimbra (author)
  • Baptista, Filipa I.University of Coimbra (author)
  • Gaspar, Joana M.University of Coimbra (author)
  • Pinheiro, Bárbara S.University of Coimbra (author)
  • Lemos, CristinaUniversity of Coimbra (author)
  • Kaufmann, Fernanda NeutzlingUniversity of Coimbra (author)
  • Morgado, CarlaUniversity of Porto (author)
  • Silva-Santos, Carla S.daUniversity of Coimbra (author)
  • Tavares, IsauraInstitute for Molecular and Cell Biology,University of Porto (author)
  • Ferreira, Samira G.University of Coimbra (author)
  • Carvalho, EugéniaUniversity of Coimbra,University of Arkansas for Medical Sciences (author)
  • Ambrósio, António F.University of Coimbra (author)
  • Cunha, Rodrigo A.University of Coimbra (author)
  • Duarte, João M.N.Lund University,Lunds universitet,Diabetes och hjärnans funktion,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Diabetes and Brain Function,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine(Swepub:lu)jo2654du (author)
  • Köfalvi, AttilaUniversity of Coimbra (author)
  • University of CoimbraUniversity of Porto (creator_code:org_t)

Related titles

  • In:Brain Research Bulletin: Elsevier BV161, s. 106-1150361-9230

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