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The cost-effectiven...
The cost-effectiveness of a uniform versus age-based threshold for one-off screening for prevention of cardiovascular disease
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- Špacírová, Zuzana (författare)
- Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP)
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Kaptoge, Stephen (författare)
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- García-Mochón, Leticia (författare)
- Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP)
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- Rodríguez Barranco, Miguel (författare)
- Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP)
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- Sánchez Pérez, María José (författare)
- University of Granada,CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP)
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- Bondonno, Nicola P. (författare)
- Edith Cowan University,Danish Cancer Society
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- Tjønneland, Anne (författare)
- Danish Cancer Society,University of Copenhagen
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- Weiderpass, Elisabete (författare)
- International Agency for Research on Cancer, World Health Organization
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- Grioni, Sara (författare)
- Istituto Nazionale dei Tumori
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- Espín, Jaime (författare)
- Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP)
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- Sacerdote, Carlotta (författare)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Schiborn, Catarina (författare)
- German Center for Diabetes Research,German Institute of Human Nutrition
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- Masala, Giovanna (författare)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
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- Colorado-Yohar, Sandra M. (författare)
- University of Antioquia,CIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council
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Kim, Lois (författare)
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- Moons, Karel G.M. (författare)
- University Medical Center Utrecht
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- Engström, Gunnar (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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- Schulze, Matthias B. (författare)
- German Center for Diabetes Research,University of Potsdam,German Institute of Human Nutrition
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Bresson, Léa (författare)
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- Moreno-Iribas, Concepción (författare)
- Health Research Institute of Navarra (IDISNA)
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- Epstein, David (författare)
- University of Granada,Health Research Institute of Navarra (IDISNA)
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(creator_code:org_t)
- 2022-10-14
- 2023
- Engelska.
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Ingår i: European Journal of Health Economics. - : Springer Science and Business Media LLC. - 1618-7598 .- 1618-7601. ; 24:7, s. 1033-1045
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The objective of this article was to assess the cost-effectiveness of screening strategies for cardiovascular diseases (CVD). A decision analytic model was constructed to estimate the costs and benefits of one-off screening strategies differentiated by screening age, sex and the threshold for initiating statin therapy (“uniform” or “age-adjusted”) from the Spanish NHS perspective. The age-adjusted thresholds were configured so that the same number of people at high risk would be treated as under the uniform threshold. Health benefit was measured in quality-adjusted life years (QALY). Transition rates were estimated from the European Prospective Investigation into Cancer and Nutrition (EPIC-CVD), a large multicentre nested case-cohort study with 12 years of follow-up. Unit costs of primary care, hospitalizations and CVD care were taken from the Spanish health system. Univariate and probabilistic sensitivity analyses were employed. The comparator was no systematic screening program. The base case model showed that the most efficient one-off strategy is to screen both men and women at 40 years old using a uniform risk threshold for initiating statin treatment (Incremental Cost-Effectiveness Ratio of €3,274/QALY and €6,085/QALY for men and women, respectively). Re-allocating statin treatment towards younger individuals at high risk for their age and sex would not offset the benefit obtained using those same resources to treat older individuals. Results are sensitive to assumptions about CVD incidence rates. To conclude, one-off screening for CVD using a uniform risk threshold appears cost-effective compared with no systematic screening. These results should be evaluated in clinical studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Health Care Service and Management, Health Policy and Services and Health Economy (hsv//eng)
Nyckelord
- Cardiovascular disease
- Cost-effectiveness
- Framingham risk score
- Screening
- Spain
- Statins
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Špacírová, Zuzan ...
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Kaptoge, Stephen
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García-Mochón, L ...
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Rodríguez Barran ...
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Sánchez Pérez, M ...
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Bondonno, Nicola ...
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visa fler...
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Tjønneland, Anne
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Weiderpass, Elis ...
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Grioni, Sara
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Espín, Jaime
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Sacerdote, Carlo ...
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Schiborn, Catari ...
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Masala, Giovanna
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Colorado-Yohar, ...
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Kim, Lois
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Moons, Karel G.M ...
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Engström, Gunnar
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Schulze, Matthia ...
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Bresson, Léa
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Moreno-Iribas, C ...
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Epstein, David
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