Search: id:"swepub:oai:lup.lub.lu.se:e9f6abd5-f444-4770-a1f0-0621b458cb43" >
The Tumbleweed: tow...
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Bromley, Elizabeth H. C.
(author)
The Tumbleweed: towards a synthetic protein motor
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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2010-09-07
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Informa UK Limited,2009
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:e9f6abd5-f444-4770-a1f0-0621b458cb43
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https://lup.lub.lu.se/record/1463189URI
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https://doi.org/10.2976/1.3111282DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Biomolecular motors have inspired the design and construction of artificial nanoscale motors and machines based on nucleic acids, small molecules, and inorganic nanostructures. However, the high degree of sophistication and efficiency of biomolecular motors, as well as their specific biological function, derives from the complexity afforded by protein building blocks. Here, we discuss a novel bottom-up approach to understanding biological motors by considering the construction of synthetic protein motors. Specifically, we present a design for a synthetic protein motor that moves along a linear track, dubbed the "Tumbleweed." This concept uses three discrete ligand-dependent DNA-binding domains to perform cyclically ligand-gated, rectified diffusion along a synthesized DNA molecule. Here we describe how de novo peptide design and molecular biology could be used to produce the Tumbleweed, and we explore the fundamental motor operation of such a design using numerical simulations. The construction of this and more sophisticated protein motors is an exciting challenge that is likely to enhance our understanding of the structure-function relationship in biological motors. [DOI: 10.2976/1.3111282]
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Added entries (persons, corporate bodies, meetings, titles ...)
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Kuwada, Nathan J.
(author)
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Zuckermann, Martin J.
(author)
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Donadini, Roberta
(author)
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Samii, Laleh
(author)
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Blab, Gerhard A.
(author)
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Gemmen, Gregory J.
(author)
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Lopez, Benjamin J.
(author)
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Curmi, Paul M. G.
(author)
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Forde, Nancy R.
(author)
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Woolfson, Derek N.
(author)
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Linke, HeinerLund University,Lunds universitet,Fasta tillståndets fysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Solid State Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)ftf-hle
(author)
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Fasta tillståndets fysikFysiska institutionen
(creator_code:org_t)
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In:HFSP Journal: Informa UK Limited3:3, s. 204-2121955-2068
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Kuwada, Nathan J ...
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Zuckermann, Mart ...
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Donadini, Robert ...
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Samii, Laleh
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Blab, Gerhard A.
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Gemmen, Gregory ...
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Lopez, Benjamin ...
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Forde, Nancy R.
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Linke, Heiner
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