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- Sandin, MarianneLund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH (author)
Is label-free LC-MS/MS ready for biomarker discovery?
- Article/chapterEnglish2015
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- 2015-03-21
- Wiley,2015
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- LIBRIS-ID:oai:lup.lub.lu.se:ea083c77-821c-48fc-a681-ceb66c0a591e
- https://lup.lub.lu.se/record/5145330URI
- https://doi.org/10.1002/prca.201400202DOI
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- Language:English
- Summary in:English
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- Label-free LC-MS methods are attractive for high-throughput quantitative proteomics, as the sample processing is straightforward and can be scaled to a large number of samples. Label-free methods therefore facilitate biomarker discovery in studies involving dozens of clinical samples. However, despite the increased popularity of label-free workflows, there is a hesitance in the research community to use it in clinical proteomics studies. Therefore, we here discuss pros and cons of label free LC-MS/MS for biomarker discovery, and delineate the main prerequisites for its successful employment. Furthermore, we cite studies where label-free LC-MS/MS was successfully used to identify novel biomarkers, and foresee an increased acceptance of label-free techniques by the proteomics community in the near future. This article is protected by copyright. All rights reserved.
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- Chawade, AakashLund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)immu-asc (author)
- Levander, FredrikLund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)tmb-fle (author)
- Institutionen för immunteknologiInstitutioner vid LTH (creator_code:org_t)
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- In:Proteomics Clinical Applications: Wiley9:3-4, s. 289-2941862-83541862-8346
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