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  • Brugulat-Serrat, AnnaCarlos III Health Institute,Pasqual Maragall Foundation for Research on Alzheimer,Hospital del Mar Medical Research Institute,Global Brain Health Institute (författare)

APOE -ε4 modulates the association between regional amyloid deposition and cognitive performance in cognitively unimpaired middle-aged individuals

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • 2023-03-01
  • Springer Science and Business Media LLC,2023

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:ea1185a4-af23-429b-bf82-28e93942b49f
  • https://lup.lub.lu.se/record/ea1185a4-af23-429b-bf82-28e93942b49fURI
  • https://doi.org/10.1186/s13550-023-00967-6DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Purpose: To determine whether the APOE-ε4 allele modulates the relationship between regional β-amyloid (Aβ) accumulation and cognitive change in middle-aged cognitively unimpaired (CU) participants. Methods: The 352 CU participants (mean aged 61.1 [4.7] years) included completed two cognitive assessments (average interval 3.34 years), underwent [18F]flutemetamol Aβ positron emission tomography (PET), T1w magnetic resonance imaging (MRI), as well as APOE genotyping. Global and regional Aβ PET positivity was assessed across five regions-of-interest by visual reading (VR) and regional Centiloids. Linear regression models were developed to examine the interaction between regional and global Aβ PET positivity and APOE-ε4 status on longitudinal cognitive change assessed with the Preclinical Alzheimer’s Cognitive Composite (PACC), episodic memory, and executive function, after controlling for age, sex, education, cognitive baseline scores, and hippocampal volume. Results: In total, 57 participants (16.2%) were VR+ of whom 41 (71.9%) were APOE-ε4 carriers. No significant APOE-ε4*global Aβ PET interactions were associated with cognitive change for any cognitive test. However, APOE-ε4 carriers who were VR+ in temporal areas (n = 19 [9.81%], p = 0.04) and in the striatum (n = 8 [4.14%], p = 0.01) exhibited a higher decline in the PACC. The temporal areas findings were replicated when regional PET positivity was determined with Centiloid values. Regionally, VR+ in the striatum was associated with higher memory decline. As for executive function, interactions between APOE-ε4 and regional VR+ were found in temporal and parietal regions, and in the striatum. Conclusion: CU APOE-ε4 carriers with a positive Aβ PET VR in regions known to accumulate amyloid at later stages of the Alzheimer’s disease (AD) continuum exhibited a steeper cognitive decline. This work supports the contention that regional VR of Aβ PET might convey prognostic information about future cognitive decline in individuals at higher risk of developing AD. ClinicalTrials.gov Identifier: NCT02485730. Registered 20 June 2015 https://clinicaltrials.gov/ct2/show/NCT02485730 and ClinicalTrials.gov Identifier:NCT02685969. Registered 19 February 2016 https://clinicaltrials.gov/ct2/show/NCT02685969.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Sánchez-Benavides, GonzaloCarlos III Health Institute,Pasqual Maragall Foundation for Research on Alzheimer,Hospital del Mar Medical Research Institute (författare)
  • Cacciaglia, RaffaeleCarlos III Health Institute,Hospital del Mar Medical Research Institute,Pasqual Maragall Foundation for Research on Alzheimer (författare)
  • Salvadó, GemmaLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Pasqual Maragall Foundation for Research on Alzheimer(Swepub:lu)ge5655sa (författare)
  • Shekari, MahnazPompeu Fabra University,Hospital del Mar Medical Research Institute,Pasqual Maragall Foundation for Research on Alzheimer (författare)
  • Collij, Lyduine E.Vrije Universiteit Amsterdam(Swepub:lu)ly4120co (författare)
  • Buckley, ChristopherUniversity College London (författare)
  • van Berckel, Bart N.M.Vrije Universiteit Amsterdam (författare)
  • Perissinotti, AndrésHospital Clínic of Barcelona,CIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) (författare)
  • Niñerola-Baizán, AidaCIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN),Hospital Clínic of Barcelona (författare)
  • Milà-Alomà, MartaCarlos III Health Institute,Pasqual Maragall Foundation for Research on Alzheimer,Hospital del Mar Medical Research Institute,Pompeu Fabra University (författare)
  • Vilor-Tejedor, NatàliaPompeu Fabra University,Pasqual Maragall Foundation for Research on Alzheimer,Center for Genomic Regulation (CRG) (författare)
  • Operto, GrégoryCarlos III Health Institute,Pasqual Maragall Foundation for Research on Alzheimer,Hospital del Mar Medical Research Institute (författare)
  • Falcon, CarlesPasqual Maragall Foundation for Research on Alzheimer,Hospital del Mar Medical Research Institute (författare)
  • Grau-Rivera, OriolHospital del Mar Medical Research Institute,Pasqual Maragall Foundation for Research on Alzheimer,Carlos III Health Institute (författare)
  • Arenaza-Urquijo, Eider M.Carlos III Health Institute,Pasqual Maragall Foundation for Research on Alzheimer,Hospital del Mar Medical Research Institute (författare)
  • Minguillón, CarolinaHospital del Mar Medical Research Institute,Pasqual Maragall Foundation for Research on Alzheimer,Carlos III Health Institute (författare)
  • Fauria, KarineCarlos III Health Institute,Pasqual Maragall Foundation for Research on Alzheimer,Hospital del Mar Medical Research Institute (författare)
  • Molinuevo, José LuisH. Lundbeck A/S,Pasqual Maragall Foundation for Research on Alzheimer (författare)
  • Suárez-Calvet, MarcCarlos III Health Institute,Hospital del Mar Medical Research Institute,Pasqual Maragall Foundation for Research on Alzheimer (författare)
  • Gispert, Juan DomingoPasqual Maragall Foundation for Research on Alzheimer,Hospital del Mar Medical Research Institute,CIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) (författare)
  • Cañas, Alba (författare)
  • Canals, Lidia (författare)
  • Iglesias, Laura (författare)
  • Marne, Paula (författare)
  • Beteta, Annabella (författare)
  • Deulofeu, Carme (författare)
  • Emilio, Maria (författare)
  • Cumplido, Irene (författare)
  • Domínguez, Ruth (författare)
  • Fuentes, Sherezade (författare)
  • Hernández, Laura (författare)
  • Vilanova, Marc (författare)
  • Solsona, Lluís (författare)
  • Huesa, Gema (författare)
  • Huguet, Jordi (författare)
  • Menchón, Tania (författare)
  • Polo, Albina (författare)
  • Pradas, Sandra (författare)
  • Sala-Vila, Aleix (författare)
  • Soteras, Anna (författare)
  • Stankeviciute, Laura (författare)
  • Akinci, Müge (författare)
  • Palpatzis, Eleni (författare)
  • Genius, Patricia (författare)
  • Rodríguez, Blanca (författare)
  • García, Marina (författare)
  • Ortiz-Romero, Paula (författare)
  • Carlos III Health InstitutePasqual Maragall Foundation for Research on Alzheimer (creator_code:org_t)
  • ALFA Study

Sammanhörande titlar

  • Ingår i:EJNMMI Research: Springer Science and Business Media LLC13:12191-219X

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