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  • Lucchini, Roberto G.Florida International University,University of Brescia (author)

Metal Exposure and SNCA rs356219 Polymorphism Associated With Parkinson Disease and Parkinsonism

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-12-09
  • Frontiers Media SA,2020

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:ea3a710f-d73b-485f-bde6-229c985e00f4
  • https://lup.lub.lu.se/record/ea3a710f-d73b-485f-bde6-229c985e00f4URI
  • https://doi.org/10.3389/fneur.2020.556337DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:145432186URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Objective: In the province of Brescia, Italy, historical neurotoxic metal exposure has occurred for several decades. This study aimed to explore the role of metal exposure and genetics on Parkinson's Disease (PD) and Parkinsonism. Methods: Cases were enrolled from four local clinics for movement disorders. Randomly selected controls non-affected by neurological or psychiatric conditions were enrolled from the same health centers keeping a similar gender ratio and age distribution as for cases. Data on sociodemographic variables, clinical onset and life habits were collected besides accurate occupational and residential history. Blood samples were collected from all participants for genotyping of target polymorphisms in genes linked to PD and/or metal transport. Results: A total number of 432 cases and 444 controls were enrolled in the study, with average age of 71 years (72.2 for cases and 70 for controls). The average age at diagnosis was 65.9 years (SD 9.9). Among the potential risk factors, family history of PD or Parkinsonism showed the strongest association with the diseases (OR = 4.2, 95% CI 2.3, 7.6 on PD; OR = 4.3, 95% CI 1.9, 9.5 for Parkinsonism), followed by polymorphism rs356219 in the alpha-synuclein (SNCA) gene (OR = 2.03, 95% CI 1.3, 3.3 for CC vs. TT on PD; OR = 2.5, 95% CI 1.1, 5.3 for CC vs. TT on Parkinsonism), exposure to metals (OR = 2.4;, 95% CI 1.3, 4.2 on PD), being born in a farm (OR = 1.8; 95% CI 1.1, 2.8 on PD; OR = 2.6; 95% CI 1.4, 4.9 on Parkinsonism) and being born in the province of Brescia (OR = 1.7; 95% CI 1.0, 2.9 on PD). Conditional OR of having PD depending by SNCA polymorphism and metal exposure highlights higher risk of PD among CC SNCA carriers and being exposed to metals. However, the interaction term was not statistically significant. Conclusions: Lifetime exposure to metals and genetic variation in SNCA gene are relevant determinants of PD and Parkinsonism in the highly industrialized area of Brescia, Italy. The lack of evidence of statistical interaction between environmental and genetic factors may be due to the low frequencies of subjects representing the exposure categories and the polymorphism variants and does not rule out the biological interaction.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Guazzetti, StefanoAzienda USL-IRCCS di Reggio Emilia (author)
  • Renzetti, StefanoUniversity of Brescia (author)
  • Broberg, KarinKarolinska Institutet,Karolinska Institute,Lund University,Lunds universitet,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Genetic Occupational and Environmental Medicine,Lund University Research Groups(Swepub:lu)kgen-kbr (author)
  • Caci, MargheritaUniversity of Brescia (author)
  • Covolo, LoredanaUniversity of Brescia (author)
  • Crippa, PatriziaAncelle della Carità, Brescia (author)
  • Gelatti, UmbertoUniversity of Brescia (author)
  • Hashim, DanaIcahn School of Medicine at Mount Sinai (author)
  • Oppini, ManuelaUniversity of Brescia (author)
  • Pepe, FulvioFondazione Poliambulanza Istituto Ospedaliero, Brescia (author)
  • Pilotto, AndreaUniversity of Brescia,Ospedale Sant'Isidoro di Trescore Balneario, Bergamo (author)
  • Passeri, ChiaraUniversity of Brescia (author)
  • Placidi, DonatellaUniversity of Brescia (author)
  • Rizzetti, Maira CristinaOspedale Sant'Isidoro di Trescore Balneario, Bergamo (author)
  • Turla, MarinellaASST Della Valcamonica (author)
  • Wahlberg, KarinLund University,Lunds universitet,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Genetic Occupational and Environmental Medicine,Lund University Research Groups(Swepub:lu)immu-kwa (author)
  • Padovani, AlessandroUniversity of Brescia (author)
  • Florida International UniversityUniversity of Brescia (creator_code:org_t)

Related titles

  • In:Frontiers in Neurology: Frontiers Media SA111664-2295

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