Search: WFRF:(Månsson S)
> (2020-2023) >
Intrahost evolution...
Intrahost evolution of the HIV-2 capsid correlates with progression to AIDS
-
- Boswell, M. T. (author)
- University of Oxford
-
- Nazziwa, J. (author)
- Lund University,Lunds universitet,Systemvirologi,Forskargrupper vid Lunds universitet,Systems Virology,Lund University Research Groups
-
- Kuroki, K. (author)
- Hokkaido University
-
show more...
-
- Palm, A. (author)
- Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,HIV-1 och HIV-2 värd interaktioner,Forskargrupper vid Lunds universitet,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine,HIV-1 and HIV-2 host interactions,Lund University Research Groups
-
- Karlson, S. (author)
- Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,HIV-1 och HIV-2 värd interaktioner,Forskargrupper vid Lunds universitet,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine,HIV-1 and HIV-2 host interactions,Lund University Research Groups
-
- Månsson, F. (author)
- Lund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups
-
Biague, A. (author)
-
da Silva, Z. J. (author)
-
Onyango, C. O. (author)
-
- de Silva, T. I. (author)
- London School of Hygiene and Tropical Medicine,University of Sheffield
-
- Jaye, A. (author)
- London School of Hygiene and Tropical Medicine
-
- Norrgren, H. (author)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Medstrand, P. (author)
- Lund University,Lunds universitet,Klinisk virologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Virology, Malmö,Lund University Research Groups
-
- Jansson, M. (author)
- Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,HIV-1 och HIV-2 värd interaktioner,Forskargrupper vid Lunds universitet,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine,HIV-1 and HIV-2 host interactions,Lund University Research Groups
-
- Maenaka, K. (author)
- Hokkaido University
-
- Rowland-Jones, S. L. (author)
- London School of Hygiene and Tropical Medicine,University of Oxford
-
- Esbjörnsson, J. (author)
- Lund University,Lunds universitet,Systemvirologi,Forskargrupper vid Lunds universitet,Systems Virology,Lund University Research Groups,University of Oxford
-
show less...
-
(creator_code:org_t)
-
- 2022-08-24
- 2022
- English.
-
In: Virus Evolution. - : Oxford University Press (OUP). - 2057-1577. ; 8:2
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- HIV-2 infection will progress to AIDS in most patients without treatment, albeit at approximately half the rate of HIV-1 infection. HIV-2 capsid (p26) amino acid polymorphisms are associated with lower viral loads and enhanced processing of T cell epitopes, which may lead to protective Gag-specific T cell responses common in slower progressors. Lower virus evolutionary rates, and positive selection on conserved residues in HIV-2 env have been associated with slower progression to AIDS. In this study we analysed 369 heterochronous HIV-2 p26 sequences from 12 participants with a median age of 30 years at enrolment. CD4% change over time was used to stratify participants into relative faster and slower progressor groups. We analysed p26 sequence diversity evolution, measured site-specific selection pressures and evolutionary rates, and determined if these evolutionary parameters were associated with progression status. Faster progressors had lower CD4% and faster CD4% decline rates. Median pairwise sequence diversity was higher in faster progressors (5.7x10-3 versus 1.4x10-3 base substitutions per site, P<0.001). p26 evolved under negative selection in both groups (dN/dS=0.12). Median virus evolutionary rates were higher in faster than slower progressors – synonymous rates: 4.6x10-3 vs. 2.3x10-3; and nonsynonymous rates: 6.9x10-4 vs. 2.7x10-4 substitutions/site/year, respectively. Virus evolutionary rates correlated negatively with CD4% change rates (ρ = -0.8, P=0.02), but not CD4% level. The signature amino acid at p26 positions 6, 12 and 119 differed between faster (6A, 12I, 119A) and slower (6G, 12V, 119P) progressors. These amino acid positions clustered near to the TRIM5α/p26 hexamer interface surface. p26 evolutionary rates were associated with progression to AIDS and were mostly driven by synonymous substitutions. Nonsynonymous evolutionary rates were an order of magnitude lower than synonymous rates, with limited amino acid sequence evolution over time within hosts. These results indicate HIV-2 p26 may be an attractive therapeutic target.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- capsid
- evolution
- HIV-2
- p26
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Boswell, M. T.
-
Nazziwa, J.
-
Kuroki, K.
-
Palm, A.
-
Karlson, S.
-
Månsson, F.
-
show more...
-
Biague, A.
-
da Silva, Z. J.
-
Onyango, C. O.
-
de Silva, T. I.
-
Jaye, A.
-
Norrgren, H.
-
Medstrand, P.
-
Jansson, M.
-
Maenaka, K.
-
Rowland-Jones, S ...
-
Esbjörnsson, J.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Infectious Medic ...
- Articles in the publication
-
Virus Evolution
- By the university
-
Lund University