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- Razumova, ZoiaKarolinska Institutet (author)
The Prognostic Role of LRIG Proteins in Endometrial Cancer
- Article/chapterEnglish2021
Publisher, publication year, extent ...
- 2021-03-17
- Stockholm :MDPI,2021
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:oru-90975
- ISSN:2072-6694
- 10616/48043hdl
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-90975URI
- https://doi.org/10.3390/cancers13061361DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-181783URI
- http://hdl.handle.net/10616/48043URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:146230995URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Funding Agency:Cancer Research Foundation in Northern Sweden
- Endometrial cancer (EC) is the most common gynecologic malignancy in Sweden and it has various prognostic factors. The LRIG family is a group of three integral surface proteins with a similar domain organization. The study aimed to explore LRIG family as prognostic factor proteins in EC. The initial study cohort included 100 women with EC who were treated at the Department of Women’s and Children’s Health, Karolinska University Hospital Solna, between 2007 and 2012. We assessed the associations between LRIG protein expression and type, grade, and stage of EC, as well as progression-free and overall survival. Immunohistochemistry results revealed that most women in the analytical sample had >50% LRIG1-, LRIG2- and LRIG3-positive cells. A statistically significant association was observed between having a high number of LRIG3-positive cells and superior overall survival (incidence rate ratio = 0.977; 95% confidence interval: 0.958–0.996, p = 0.019). Moreover, positive LRIG3 staining of the cell membrane was associated with reducing in the risk of death (hazard ratio = 0.23; 95% confidence interval: 0.09–0.57). Our results show that LRIG3 expression might be a prognostic factor in EC. The role of LRIG1 and LRIG2 expression remains to be further investigated.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- LRIG1
- LRIG2
- LRIG3
- endometrial cancer
- prognosis
Added entries (persons, corporate bodies, meetings, titles ...)
- Oda, HusamUmeå universitet,Patologi(Swepub:umu)huod0001 (author)
- Govorov, IgorKarolinska Institutet (author)
- Lundin, EvaUmeå universitet,Patologi(Swepub:umu)evlu0001 (author)
- Östensson, EllinorKarolinska Institutet (author)
- Lindquist, DavidUmeå universitet,Professionell utveckling(Swepub:umu)dali0066 (author)
- Mints, Miriam,1958-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Division of Neonatology, Obstetrics and Gynecology, Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden(Swepub:oru)mms (author)
- Karolinska InstitutetPatologi (creator_code:org_t)
- Karolinska Institutet
- Karolinska Institutet
Related titles
- In:CancersStockholm : MDPI13:62072-6694
Internet link
- https://doi.org/10.3390/cancers13061361Fulltext
- https://www.mdpi.com/2072-6694/13/6/1361/pdf
- https://umu.diva-portal.org/smash/get/diva2:1541605/FULLTEXT01.pdffulltext:print
- http://hdl.handle.net/10616/48043FULLTEXT
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-90975
- https://doi.org/10.3390/cancers13061361
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-181783
- http://hdl.handle.net/10616/48043
- http://kipublications.ki.se/Default.aspx?queryparsed=id:146230995
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