MC1R is dispensable for the proteinuria reducing and glomerular protective effect of melanocortin therapy

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Qiao, YingjinZhengzhou University (author)

MC1R is dispensable for the proteinuria reducing and glomerular protective effect of melanocortin therapy

Article/chapterEnglish2016

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2016-06-08
Springer Science and Business Media LLC,2016

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LIBRIS-ID:oai:lup.lub.lu.se:eab6b76c-4f84-4afd-a14b-679bc6895776
https://lup.lub.lu.se/record/eab6b76c-4f84-4afd-a14b-679bc6895776URI
https://doi.org/10.1038/srep27589DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

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Melanocortin therapy by using adrenocorticotropic hormone (ACTH) or non-steroidogenic melanocortin peptides attenuates proteinuria and glomerular injury in experimental glomerular diseases and induces remission of nephrotic syndrome in patients with diverse glomerulopathies, even those resistant to steroids. The underlying mechanism remains elusive, but the role of melanocortin 1 receptor (MC1R) has been implicated and was examined here. Four patients with congenital red hair color and nephrotic syndrome caused by idiopathic membranous nephropathy or focal segmental glomerulosclerosis were confirmed by gene sequencing to bear dominant-negative MC1R mutations. Despite prior corticosteroid resistance, all patients responded to ACTH monotherapy and ultimately achieved clinical remission, inferring a steroidogenic-independent and MC1R-dispensable anti-proteinuric effect of melanocortin signaling. In confirmatory animal studies, the protective effect of [Nle4, D-Phe7 ]-α-melanocyte stimulating hormone (NDP-MSH), a potent non-steroidogenic pan-melanocortin receptor agonist, on the lipopolysaccharide elicited podocytopathy was completely preserved in MC1R-null mice, marked by reduced albuminuria and diminished histologic signs of podocyte injury. Moreover, in complementary in vitro studies, NDP-MSH attenuated the lipopolysaccharide elicited apoptosis, hypermotility and impairment of filtration barrier function equally in primary podocytes derived from MC1R-null and wild-type mice. Collectively, our findings suggest that melanocortin therapy confers a proteinuria reducing and podoprotective effect in proteinuric glomerulopathies via MC1R-independent mechanisms.

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Berg, Anna LenaLund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)njur-alb (author)
Wang, PeiBrown University (author)
Ge, YanBrown University (author)
Quan, SongxiaBrown University (author)
Zhou, SijieBrown University (author)
Wang, HaiBrown University (author)
Liu, ZhangsuoZhengzhou University (author)
Gong, RujunBrown University (author)
Zhengzhou UniversityNjurmedicin (creator_code:org_t)

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In:Scientific Reports: Springer Science and Business Media LLC62045-2322

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By the author/editor: Qiao, Yingjin; Berg, Anna Lena; Wang, Pei; Ge, Yan; Quan, Songxia; Zhou, Sijie; show more...; Wang, Hai; Liu, Zhangsuo; Gong, Rujun; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Urology and Neph ...

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