WFRF:(Klein W.)
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- Wang, YLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups (author)
Functional homology between N-myc and c-myc in murine plasmacytomagenesis : plasmacytoma development in N-myc transgenic mice
- Article/chapterEnglish1992
Publisher, publication year, extent ...
- 1992
- 7 s.
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:eadcf944-2dfe-4770-ac08-8a05413060a7
- https://lup.lub.lu.se/record/eadcf944-2dfe-4770-ac08-8a05413060a7URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Mouse plasmacytomas induced by pristane oil alone, or in combination with Abelson murine leukemia virus (A-MuLV), regularly carry one of three alternative chromosomal translocations that juxtapose c-myc to immunoglobulin heavy- or light-chain loci. E mu-c-myc transgenic mice develop translocation-free plasmacytomas after induction by pristane oil and/or A-MuLV [Sugiyama, H., Silva, S., Wang, Y., Weber, G., Babonits, M., Rosen, A., Wiener, F. & Klein, G. (1990). Int. J. Cancer, 46, 845-852]. In order to test whether another member of the myc family, N-myc, could play a similar role as c-myc, we treated E mu-N-myc transgenic mice with pristane and helper-free A-MuLV. Of 20 mice that received a single pristane injection followed by A-MuLV, 17 developed plasmacytomas with a mean latency period of 54 +/- 20 days. In a corresponding group that only received a single pristane injection, five out of six transgenic mice developed plasmacytomas with a mean latency period of 142 +/- 32 days. However, after three monthly injections of pristane, all 15 transgenic mice developed plasmacytomas with a mean latency period of 128 +/- 20 days. All plasmacytomas expressed the N-myc transgene, while none of them expressed either c-myc or endogenous N-myc. None of the tumors carried the usual plasmacytoma-associated translocations.
Subject headings and genre
- Abelson murine leukemia virus
- Animals
- Carcinogens
- DNA
- DNA, Neoplasm
- Enhancer Elements, Genetic
- Genes, Immunoglobulin
- Genes, myc
- Immunoglobulin Heavy Chains
- Immunoglobulin Light Chains
- Introns
- Mice
- Mice, Transgenic
- Plasmacytoma
- RNA
- RNA, Neoplasm
- Terpenes
- Translocation, Genetic
Added entries (persons, corporate bodies, meetings, titles ...)
- Sugiyama, H (author)
- Axelson, HKarolinska Institutet,Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)molm-hax (author)
- Panda, C K (author)
- Babonits, M (author)
- Ma, A (author)
- Steinberg, J M (author)
- Alt, F W (author)
- Klein, G (author)
- Wiener, F (author)
- KirurgiForskargrupper vid Lunds universitet (creator_code:org_t)
Related titles
- In:Oncogene7:6, s. 7-12410950-9232
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- Sugiyama, H
- Axelson, H
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- Steinberg, J M
- Alt, F W
- Klein, G
- Wiener, F
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- Oncogene
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- Lund University
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