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Functional homology...
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Wang, YLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
(author)
Functional homology between N-myc and c-myc in murine plasmacytomagenesis : plasmacytoma development in N-myc transgenic mice
- Article/chapterEnglish1992
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:eadcf944-2dfe-4770-ac08-8a05413060a7
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https://lup.lub.lu.se/record/eadcf944-2dfe-4770-ac08-8a05413060a7URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Mouse plasmacytomas induced by pristane oil alone, or in combination with Abelson murine leukemia virus (A-MuLV), regularly carry one of three alternative chromosomal translocations that juxtapose c-myc to immunoglobulin heavy- or light-chain loci. E mu-c-myc transgenic mice develop translocation-free plasmacytomas after induction by pristane oil and/or A-MuLV [Sugiyama, H., Silva, S., Wang, Y., Weber, G., Babonits, M., Rosen, A., Wiener, F. & Klein, G. (1990). Int. J. Cancer, 46, 845-852]. In order to test whether another member of the myc family, N-myc, could play a similar role as c-myc, we treated E mu-N-myc transgenic mice with pristane and helper-free A-MuLV. Of 20 mice that received a single pristane injection followed by A-MuLV, 17 developed plasmacytomas with a mean latency period of 54 +/- 20 days. In a corresponding group that only received a single pristane injection, five out of six transgenic mice developed plasmacytomas with a mean latency period of 142 +/- 32 days. However, after three monthly injections of pristane, all 15 transgenic mice developed plasmacytomas with a mean latency period of 128 +/- 20 days. All plasmacytomas expressed the N-myc transgene, while none of them expressed either c-myc or endogenous N-myc. None of the tumors carried the usual plasmacytoma-associated translocations.
Subject headings and genre
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Abelson murine leukemia virus
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Animals
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Carcinogens
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DNA
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DNA, Neoplasm
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Enhancer Elements, Genetic
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Genes, Immunoglobulin
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Genes, myc
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Immunoglobulin Heavy Chains
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Immunoglobulin Light Chains
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Introns
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Mice
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Mice, Transgenic
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Plasmacytoma
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RNA
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RNA, Neoplasm
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Terpenes
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Translocation, Genetic
Added entries (persons, corporate bodies, meetings, titles ...)
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Sugiyama, H
(author)
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Axelson, HKarolinska Institutet,Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)molm-hax
(author)
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Panda, C K
(author)
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Babonits, M
(author)
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Ma, A
(author)
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Steinberg, J M
(author)
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Alt, F W
(author)
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Klein, G
(author)
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Wiener, F
(author)
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KirurgiForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
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In:Oncogene7:6, s. 7-12410950-9232
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Oncogene
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Wang, Y
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Sugiyama, H
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Axelson, H
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Panda, C K
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Babonits, M
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Ma, A
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Steinberg, J M
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Alt, F W
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Klein, G
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Wiener, F
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Oncogene
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Lund University