Sökning: WFRF:(Thurston Sally W) >
PUFA status and met...
PUFA status and methylmercury exposure are not associated with leukocyte telomere length in mothers or their children in the seychelles child development study
-
- Yeates, Alison J. (författare)
- University of Ulster
-
- Thurston, Sally W. (författare)
- University of Rochester
-
- Li, Huiqi (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
-
visa fler...
-
- Mulhern, Maria S. (författare)
- University of Ulster
-
- McSorley, Emeir M. (författare)
- University of Ulster
-
- Watson, Gene E. (författare)
- University of Rochester
-
- Shamlaye, Conrad F. (författare)
- Ministry of Health, Seychelles
-
- Strain, J. J. (författare)
- University of Ulster
-
- Myers, Gary J. (författare)
- University of Rochester
-
- Davidson, Philip W. (författare)
- University of Rochester
-
- van Wijngaarden, Edwin (författare)
- University of Rochester
-
- Broberg, Karin (författare)
- Karolinska Institutet,Karolinska Institute
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska 7 s.
-
Ingår i: Journal of Nutrition. - : Elsevier BV. - 0022-3166 .- 1541-6100. ; 147:11, s. 2018-2024
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://academic.oup...
-
https://lup.lub.lu.s...
-
https://doi.org/10.3...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Leukocyte telomere length (TL) is associated with age-related diseases and early mortality, but there is a lack of data on the determinants of TL in early life. Evidence suggests that dietary intake ofmarine n-3 (v-3) polyunsaturated fatty acids (PUFAs) is protective of telomere attrition, yet the effect of methylmercury exposure, also found in fish, on TL is unknown. Objective: The aim of this study was to investigate the associations between prenatal PUFA status, methylmercury exposure, and TL in mothers and children in the SCDS (Seychelles Child Development Study), for whom fish consumption is high. Methods: Blood samples collected from 229 mothers (at 28 wk gestation and delivery) and children (at 5 y of age) in the SCDS first nutrition cohort were analyzed for PUFA concentrations. Prenatal mercury was measured in maternal hair collected at delivery. Postnatalmercury was alsomeasured in children's hair samples with the use of a cumulativemetric derived from values obtained at 3-5 y of age. Relative TL wasmeasured in blood obtained from mothers at delivery, in cord blood, and in children at 5 y of age by quantitative polymerase chain reaction. Linear regression models were used to investigate the associations between PUFA status, methylmercury exposure, and TL. Results: Neither prenatal PUFA status or methylmercury exposure was associated with TL of the mother or child or with TL attrition rate. However, a higher prenatal n-6:n-3 PUFA ratiowas significantly associated with longer TLs in the mothers (β = 0.001, P = 0.048). Child PUFA status andmethylmercury exposurewere not associated with child TL. However, higher family Hollingshead socioeconomic status (SES) scores at 9 mo of agewere significantly associatedwith longer TLs in cord blood (β = 0.005, P=0.03). Conclusions: We found no evidence that PUFA status or methylmercury exposure are determinants of TL in either the mother or child. However, our results support the hypothesis that family SES may be associated with child TL.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Fish consumption
- Maternal infant nutrition
- Methylmercury exposure
- Polyunsaturated fatty acid status
- Pregnancy
- Seychelles Child Development Study
- Telomere length
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Yeates, Alison J ...
-
Thurston, Sally ...
-
Li, Huiqi
-
Mulhern, Maria S ...
-
McSorley, Emeir ...
-
Watson, Gene E.
-
visa fler...
-
Shamlaye, Conrad ...
-
Strain, J. J.
-
Myers, Gary J.
-
Davidson, Philip ...
-
van Wijngaarden, ...
-
Broberg, Karin
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Hälsovetenskap
-
och Arbetsmedicin oc ...
- Artiklar i publikationen
-
Journal of Nutri ...
- Av lärosätet
-
Lunds universitet
-
Karolinska Institutet