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- Davidsson, JosefLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine (author)
Constitutional trisomy 8 mosaicism as a model for epigenetic studies of aneuploidy.
- Article/chapterEnglish2013
Publisher, publication year, extent ...
- 2013-07-01
- Springer Science and Business Media LLC,2013
- electronicrdacarrier
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- LIBRIS-ID:oai:lup.lub.lu.se:eb04de37-180d-442c-8257-f5ddae468e18
- https://lup.lub.lu.se/record/3956290URI
- https://doi.org/10.1186/1756-8935-6-18DOI
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- Language:English
- Summary in:English
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- To investigate epigenetic patterns associated with aneuploidy we used constitutional trisomy 8 mosaicism (CT8M) as a model, enabling analyses of single cell clones, harboring either trisomy or disomy 8, from the same patient; this circumvents any bias introduced by using cells from unrelated, healthy individuals as controls. We profiled gene and miRNA expression as well as genome-wide and promoter specific DNA methylation and hydroxymethylation patterns in trisomic and disomic fibroblasts, using microarrays and methylated DNA immunoprecipitation.
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- Veerla, SrinivasLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Division of Clinical Genetics,Department of Laboratory Medicine(Swepub:lu)klin-sve (author)
- Johansson, BertilLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)kgen-bjo (author)
- Avdelningen för klinisk genetikInstitutionen för laboratoriemedicin (creator_code:org_t)
Related titles
- In:Epigenetics & Chromatin: Springer Science and Business Media LLC6:11756-8935
Internet link
- https://portal.research.lu.se/files/3511173/4146448FULLTEXT
- http://www.ncbi.nlm.nih.gov/pubmed/23816241?dopt=AbstractFULLTEXT
- http://dx.doi.org/10.1186/1756-8935-6-18FULLTEXT
- https://epigeneticsandchromatin.biomedcentral.com/track/pdf/10.1186/1756-8935-6-18
- https://lup.lub.lu.se/record/3956290
- https://doi.org/10.1186/1756-8935-6-18
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