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Mass Spectrometry-Based Plasma Proteomics : Considerations from Sample Collection to Achieving Translational Data
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- Ignjatovic, Vera (författare)
- Murdoch Childrens Res Inst, Haematol Res, Parkville, Vic 3052, Australia.;Univ Melbourne, Dept Paediat, Parkville, Vic 3052, Australia.
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- Geyer, Philipp E. (författare)
- Univ Copenhagen, Fac Hlth Sci, NNF Ctr Prot Res, DK-2200 Copenhagen, Denmark.;Max Planck Inst Biochem, Dept Prote & Signal Transduct, D-82152 Martinsried, Germany.
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- Palaniappan, Krishnan K. (författare)
- Freenome, 259 East Grand Ave, San Francisco, CA 94080 USA.
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- Chaaban, Jessica E. (författare)
- Murdoch Childrens Res Inst, Haematol Res, Parkville, Vic 3052, Australia.
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- Omenn, Gilbert S. (författare)
- Univ Michigan, Dept Computat Med & Bioinformat, 100 Washtenaw Ave, Ann Arbor, MI 48109 USA.;Univ Michigan, Dept Human Genet, 100 Washtenaw Ave, Ann Arbor, MI 48109 USA.;Univ Michigan, Dept Internal Med, 100 Washtenaw Ave, Ann Arbor, MI 48109 USA.;Univ Michigan, Sch Publ Hlth, 100 Washtenaw Ave, Ann Arbor, MI 48109 USA.
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- Baker, Mark S. (författare)
- Macquarie Univ, Fac Med & Hlth Sci, Dept Biomed Sci, 75 Talavera Rd, N Ryde, NSW 2109, Australia.
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- Deutsch, Eric W. (författare)
- Inst Syst Biol, 401 Terry Ave North, Seattle, WA 98109 USA.
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- Schwenk, Jochen M. (författare)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
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Murdoch Childrens Res Inst, Haematol Res, Parkville, Vic 3052, Australia;Univ Melbourne, Dept Paediat, Parkville, Vic 3052, Australia. Univ Copenhagen, Fac Hlth Sci, NNF Ctr Prot Res, DK-2200 Copenhagen, Denmark.;Max Planck Inst Biochem, Dept Prote & Signal Transduct, D-82152 Martinsried, Germany. (creator_code:org_t)
- 2019-10-01
- 2019
- Engelska.
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Ingår i: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 18:12, s. 4085-4097
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The proteomic analysis of human blood and blood-derived products (e.g., plasma) offers an attractive avenue to translate research progress from the laboratory into the clinic. However, due to its unique protein composition, performing proteomics assays with plasma is challenging. Plasma proteomics has regained interest due to recent technological advances, but challenges imposed by both complications inherent to studying human biology (e.g., interindividual variability) and analysis of biospecimens (e.g., sample variability), as well as technological limitations remain. As part of the Human Proteome Project (HPP), the Human Plasma Proteome Project (HPPP) brings together key aspects of the plasma proteomics pipeline. Here, we provide considerations and recommendations concerning study design, plasma collection, quality metrics, plasma processing workflows, mass spectrometry (MS) data acquisition, data processing, and bioinformatic analysis. With exciting opportunities in studying human health and disease though this plasma proteomics pipeline, a more informed analysis of human plasma will accelerate interest while enhancing possibilities for the incorporation of proteomics-scaled assays into clinical practice.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Nyckelord
- plasma
- serum
- blood
- Human Proteome Project (HPP)
- Human Plasma Proteome Project (HPPP)
- study design
- sample collection
- quality metrics
- plasma processing workflows
- data acquisition
- mass spectrometry (MS)
- data processing
- bioinformatic analysis
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