(WFRF:(Looi Jeffrey C. L.))
Search: (WFRF:(Looi Jeffrey C. L.)) > (2020-2023) > Structural and func...
- 3 of 3
- Previous record
- Next record
- To hitlist
- Owens-Walton, ConorAustralian National University (author)
Structural and functional neuroimaging changes associated with cognitive impairment and dementia in Parkinson's disease
- Article/chapterEnglish2021
Publisher, publication year, extent ...
- Elsevier BV,2021
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:ecf84f5c-d753-4837-ae81-359cacff859d
- https://lup.lub.lu.se/record/ecf84f5c-d753-4837-ae81-359cacff859dURI
- https://doi.org/10.1016/j.pscychresns.2021.111273DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- This study seeks a better understanding of possible pathophysiological mechanisms associated with cognitive impairment and dementia in Parkinson's disease using structural and functional MRI. We investigated resting-state functional connectivity of important subdivisions of the caudate nucleus, putamen and thalamus, and also how the morphology of these structures are impacted in the disorder. We found cognitively unimpaired Parkinson's disease subjects (n = 33), compared to controls (n = 26), display increased functional connectivity of the dorsal caudate, anterior putamen and mediodorsal thalamic subdivisions with areas across the frontal lobe, as well as reduced functional connectivity of the dorsal caudate with posterior cortical and cerebellar regions. Compared to cognitively unimpaired subjects, those with mild cognitive impairment (n = 22) demonstrated reduced functional connectivity of the mediodorsal thalamus with the paracingulate cortex, while also demonstrating increased functional connectivity of the mediodorsal thalamus with the posterior cingulate cortex, compared to subjects with dementia (n = 17). Extensive volumetric and surface-based deflation was found in subjects with dementia compared to cognitively unimpaired Parkinson's disease participants and controls. Our research suggests that structures within basal ganglia-thalamocortical circuits are implicated in cognitive impairment and dementia in Parkinson's disease, with cognitive impairment and dementia associated with a breakdown in functional connectivity of the mediodorsal thalamus with para- and posterior cingulate regions of the brain respectively.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
- Functional magnetic resonance imaging
- Magnetic resonance imaging
- Mild cognitive impairment
- Morphology
Added entries (persons, corporate bodies, meetings, titles ...)
- Jakabek, DavidUniversity of Wollongong (author)
- Power, Brian D.University of Notre Dame Australia (author)
- Walterfang, MarkUniversity of Melbourne (author)
- Hall, SaraLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-sha (author)
- van Westen, DanielleLund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)ront-dva (author)
- Looi, Jeffrey C.L.Australian National University,University of Melbourne (author)
- Shaw, MarnieAustralian National University (author)
- Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)mphy-ohn (author)
- Australian National UniversityUniversity of Wollongong (creator_code:org_t)
Related titles
- In:Psychiatry Research - Neuroimaging: Elsevier BV3120925-4927
Internet link
Find in a library
- Psychiatry Research - Neuroimaging (Search for host publication in LIBRIS)
To the university's database
- 3 of 3
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Owens-Walton, Co ...
- Jakabek, David
- Power, Brian D.
- Walterfang, Mark
- Hall, Sara
- van Westen, Dani ...
- show more...
- Looi, Jeffrey C. ...
- Shaw, Marnie
- Hansson, Oskar
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Neurology
- Articles in the publication
- Psychiatry Resea ...
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
