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Late-Life Depressio...
Late-Life Depression Is Associated With Reduced Cortical Amyloid Burden : Findings From the Alzheimer's Disease Neuroimaging Initiative Depression Project
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- Mackin, R. Scott (författare)
- San Francisco Veterans Administration Medical Center,University of California, San Francisco
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- Insel, Philip S. (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,University of California, San Francisco
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- Landau, Susan (författare)
- University of California, Berkeley
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- Bickford, David (författare)
- University of California, San Francisco
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- Morin, Ruth (författare)
- San Francisco Veterans Administration Medical Center
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- Rhodes, Emma (författare)
- San Francisco Veterans Administration Medical Center
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- Tosun, Duygu (författare)
- University of California, San Francisco,San Francisco Veterans Administration Medical Center
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- Rosen, Howie J. (författare)
- University of California, San Francisco
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- Butters, Meryl (författare)
- University of Pittsburgh
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- Aisen, Paul (författare)
- University of Southern California
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- Raman, Rema (författare)
- University of Southern California
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- Saykin, Andrew (författare)
- Indiana University
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- Toga, Arthur (författare)
- University of Southern California
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- Jack, Clifford (författare)
- Mayo Clinic Minnesota
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- Koeppe, Robert (författare)
- University of Michigan
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- Weiner, Michael W. (författare)
- San Francisco Veterans Administration Medical Center,University of California, San Francisco
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- Nelson, Craig (författare)
- University of California, San Francisco
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(creator_code:org_t)
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- Elsevier BV, 2021
- 2021
- Engelska 9 s.
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Ingår i: Biological Psychiatry. - : Elsevier BV. - 0006-3223. ; 89:8, s. 757-765
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: We evaluated the role of cortical amyloid deposition as a factor contributing to memory dysfunction and increased risk of dementia associated with late-life depression (LLD). Methods: A total of 119 older adult participants with a current diagnosis of major depression (LLD) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) Depression Project study and 119 nondepressed (ND) cognitively unimpaired participants matched on age, sex, and APOE genotype were obtained from the ADNI database. Results: Thirty-three percent of LLD participants met ADNI criteria for mild cognitive impairment. Compared with ND individuals, the LLD group exhibited less global amyloid beta (Aβ) accumulation (p = .05). The proportion of amyloid positivity in the LLD group was 19.3% compared with 31.1% for the ND participants (p = .02). Among LLD participants, global Aβ was not associated with lifetime number of depressive episodes, lifetime length of depression, length of lifetime selective serotonin reuptake inhibitor use, or lifetime length of untreated depression (p >. 21 for all). Global Aβ was associated with worse memory performance (p = .05). Similar results were found in secondary analyses restricting comparisons to the cognitively unimpaired LLD participants as well as when comparing the LLD group with an ND group that included participants with mild cognitive impairment. Conclusions: Contrary to expectation, the LLD group showed less Aβ deposition than the ND group and Aβ deposition was not associated with depression history characteristics. Aβ was associated with memory, but this relationship did not differ between LLD and ND. Our results suggest that memory deficits and accelerated cognitive decline reported in previous studies of LLD are not due to greater cortical Aβ accumulation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Alzheimer's disease
- Amyloid
- Cognition
- Depressive symptoms
- Late-life depression
- Mild cognitive impairment
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Mackin, R. Scott
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Insel, Philip S.
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Landau, Susan
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Bickford, David
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Morin, Ruth
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Rhodes, Emma
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visa fler...
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Tosun, Duygu
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Rosen, Howie J.
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Butters, Meryl
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Aisen, Paul
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Raman, Rema
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Saykin, Andrew
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Toga, Arthur
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Jack, Clifford
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Koeppe, Robert
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Weiner, Michael ...
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Nelson, Craig
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visa färre...
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