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  • Kotarsky, KnutLund University,Lunds universitet,Slemhinnans immunologi,Forskargrupper vid Lunds universitet,Mucosal Immunology,Lund University Research Groups (author)

Lysophosphatidic Acid Binds to and Activates GPR92, a G Protein-Coupled Receptor Highly Expressed in Gastrointestinal Lymphocytes

  • Article/chapterEnglish2006

Publisher, publication year, extent ...

  • 2006-05-01
  • American Society for Pharmacology & Experimental Therapeutics (ASPET),2006

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:ee7c2d99-9007-41a9-b3b5-16add4b46fe7
  • https://lup.lub.lu.se/record/157093URI
  • https://doi.org/10.1124/jpet.105.098848DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:1960110URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Here, the ligand binding, activation, and tissue distribution of the orphan G protein-coupled receptor (GPCR) GPR92 were studied. GPR92 binds and is activated by compounds based on the lysophosphatidic acid (LPA) backbone. The binding of LPA to GPR92 was of high affinity (K(D) = 6.4 +/- 0.9 nM) and led to an increase in both phosphoinositide hydrolysis and cAMP production. GPR92 is atypical in that it has a low sequence homology with the classic LPA(1-3) receptors (21-22%). Expression of GPR92 is mainly found in heart, placenta, spleen, brain, lung, and gut. Notably, GPR92 is highly expressed in the lymphocyte compartment of the gastrointestinal tract. It is the most abundant GPCR activated by LPA found in the small intestinal intraepithelial CD8+ cytotoxic T cells.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Boketoft, Ake (author)
  • Bristulf, Jesper (author)
  • Nilsson, NiclasLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine(Swepub:lu)mphy-nni (author)
  • Norberg, Ake (author)
  • Hansson, StefanLund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)gyn-sha (author)
  • Sillard, Rannar (author)
  • Owman, ChristerLund University,Lunds universitet,Drug Target Discovery,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)mphy-cow (author)
  • Leeb-Lundberg, FredrikLund University,Lunds universitet,Drug Target Discovery,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)mphy-fle (author)
  • Olde, BjörnLund University,Lunds universitet,Drug Target Discovery,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)mphy-bol (author)
  • Slemhinnans immunologiForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Journal of Pharmacology and Experimental Therapeutics: American Society for Pharmacology & Experimental Therapeutics (ASPET)318:2, s. 619-6281521-01030022-3565

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