Search: WFRF:(Chaudhuri K Ray) >
Comparative Effecti...
-
Antonini, AngeloUniversity of Padova
(author)
Comparative Effectiveness of Device-Aided Therapies on Quality of Life and Off-Time in Advanced Parkinson’s Disease : A Systematic Review and Bayesian Network Meta-analysis
- Article/chapterEnglish2022
Publisher, publication year, extent ...
-
2022-11-21
-
Springer Science and Business Media LLC,2022
-
15 s.
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:ef8e9499-b83a-4233-94ec-8932072ffbba
-
https://lup.lub.lu.se/record/ef8e9499-b83a-4233-94ec-8932072ffbbaURI
-
https://doi.org/10.1007/s40263-022-00963-9DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:for swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Introduction: Research comparing levodopa/carbidopa intestinal gel (LCIG), deep brain stimulation (DBS), and continuous subcutaneous apomorphine infusion (CSAI) for advanced Parkinson’s disease (PD) is lacking. This network meta-analysis (NMA) assessed the comparative effectiveness of LCIG, DBS, CSAI and best medical therapy (BMT) in reducing off-time and improving quality of life (QoL) in patients with advanced PD. Methods: A systematic literature review was conducted for randomized controlled trials (RCTs), observational and interventional studies from January 2003 to September 2019. Data extracted at baseline and 6 months were off-time, as reported by diary or Unified Parkinson’s Disease Rating Scale Part IV item 39, and QoL, as reported by Parkinson’s Disease Questionnaire (PDQ-39/PDQ-8). Bayesian NMA was performed to estimate pooled treatment effect sizes and to rank treatments in order of effectiveness. Results: A total of 22 studies fulfilled the inclusion criteria (n = 2063 patients): four RCTs, and 16 single-armed, one 2-armed and one 3-armed prospective studies. Baseline mean age was between 55.5–70.9 years, duration of PD was 9.1–15.3 years, off-time ranged from 5.4 to 8.7 h/day in 9 studies, and PDQ scores ranged from 28.8 to 67.0 in 19 studies. Levodopa/carbidopa intestinal gel and DBS demonstrated significantly greater improvement in off-time and QoL at 6 months compared with CSAI and BMT (p < 0.05). There was no significant difference in the effects of LCIG and DBS, but DBS was ranked first for reduction in off-time, and LCIG was ranked first for improvement in QoL. Conclusions: This NMA found that LCIG and DBS were associated with superior improvement in off-time and PD-related QoL compared with CSAI and BMT at 6 months after treatment initiation. This comparative effectiveness research may assist providers, patients, and caregivers in the selection of the optimal device-aided therapy.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Pahwa, RajeshUniversity of Kansas
(author)
-
Odin, PerLund University,Lunds universitet,Restorative Parkinson Unit,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)med-poi
(author)
-
Isaacson, Stuart H.
(author)
-
Merola, AristideOhio State University
(author)
-
Wang, LinJohns Hopkins Bloomberg School of Public Health,AbbVie Inc.
(author)
-
Kandukuri, Prasanna L.AbbVie Inc.
(author)
-
Alobaidi, AliAbbVie Inc.,University of Illinois at Chicago
(author)
-
Yan, Connie H.University of Illinois at Chicago,AbbVie Inc.
(author)
-
Bao, YanjunAbbVie Inc.
(author)
-
Zadikoff, CindyAbbVie Inc.
(author)
-
Parra, Juan CarlosAbbVie Inc.
(author)
-
Bergmann, LarsAbbVie Inc.
(author)
-
Chaudhuri, K. RayKing's College Hospital
(author)
-
University of PadovaUniversity of Kansas
(creator_code:org_t)
Related titles
-
In:CNS Drugs: Springer Science and Business Media LLC36:12, s. 1269-12831172-70471179-1934
Internet link
Find in a library
-
CNS Drugs
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Antonini, Angelo
-
Pahwa, Rajesh
-
Odin, Per
-
Isaacson, Stuart ...
-
Merola, Aristide
-
Wang, Lin
-
show more...
-
Kandukuri, Prasa ...
-
Alobaidi, Ali
-
Yan, Connie H.
-
Bao, Yanjun
-
Zadikoff, Cindy
-
Parra, Juan Carl ...
-
Bergmann, Lars
-
Chaudhuri, K. Ra ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
- Articles in the publication
-
CNS Drugs
- By the university
-
Lund University