Sökning: (WFRF:(Ioannidis John P A))
> (2006-2009) >
Expectations and ch...
-
Vineis, Paolo
(författare)
Expectations and challenges stemming from genome-wide association studies
- Artikel/kapitelEngelska2008
Förlag, utgivningsår, omfång ...
-
2008-08-04
-
Oxford University Press (OUP),2008
Nummerbeteckningar
-
LIBRIS-ID:oai:lup.lub.lu.se:efb69fb8-5903-46a7-8308-264499637fe9
-
https://lup.lub.lu.se/record/1283852URI
-
https://doi.org/10.1093/mutage/gen042DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:art swepub-publicationtype
-
Ämneskategori:vet swepub-contenttype
Anmärkningar
-
There are considerable expectations about the ability of genome-wide association (GWA) studies to make exciting discoveries about the role of genes in common diseases. GWA studies may allow researchers to identify causal pathways that have not been unveiled before, thus opening new avenues to disease understanding, prevention and therapy. However, there are still many open challenges. One is how to analyse these studies. The problem of false positives and false negatives provides an interesting methodological stimulus to find optimal solutions. Once main genetic effects have been concretely documented, the next question is how to proceed with the investigation of gene-gene and gene-environment interactions. It is possible that what really counts is not the main effect of genes but complex interactions. Finding and interpreting such interactions is not straightforward. Finally, continuous updated integration of all evidence, from both old studies, current GWA investigations and future replication studies, and careful interpretation of the strength of the evidence are crucial to maximize transparency and lead to informative selection of the next steps of research in this field. The present Commentary is a report of an Environmental Cancer Risk, Nutrition and Individual Susceptibility network Workshop held in Venice in October 2007 and discusses some of the problems outlined above, with examples.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Brennan, Paul
(författare)
-
Canzian, Federico
(författare)
-
Ioannidis, John P. A.
(författare)
-
Matullo, Giuseppe
(författare)
-
Ritchie, Marylyn
(författare)
-
Strömberg, UlfLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)ymed-ust
(författare)
-
Taioli, Emanuela
(författare)
-
Thompson, John
(författare)
-
Avdelningen för arbets- och miljömedicinInstitutionen för laboratoriemedicin
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Mutagenesis: Oxford University Press (OUP)23:6, s. 439-4440267-83571464-3804
Internetlänk
Hitta via bibliotek
Till lärosätets databas