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Ribosomal RNA 2′-O-...
Ribosomal RNA 2′-O-methylation dynamics impact cell fate decisions
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- Häfner, Sophia J. (author)
- University of Copenhagen
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- Jansson, Martin D. (author)
- University of Copenhagen
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- Altinel, Kübra (author)
- University of Copenhagen
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- Andersen, Kasper L. (author)
- University of Copenhagen
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- Abay-Nørgaard, Zehra (author)
- University of Copenhagen
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- Ménard, Patrice (author)
- University of Copenhagen
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- Fontenas, Martin (author)
- University of Copenhagen
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- Sørensen, Daniel M. (author)
- University of Copenhagen
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- Gay, David M. (author)
- University of Copenhagen
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- Arendrup, Frederic S. (author)
- University of Copenhagen
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- Tehler, Disa (author)
- University of Copenhagen
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- Krogh, Nicolai (author)
- University of Copenhagen
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- Nielsen, Henrik (author)
- University of Copenhagen
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- Kraushar, Matthew L. (author)
- Max Planck Institute for Molecular Genetics
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- Kirkeby, Agnete (author)
- Lund University,Lunds universitet,Human neural utvecklingsbiologi,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Human Neural Developmental Biology,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,University of Copenhagen
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- Lund, Anders H. (author)
- University of Copenhagen
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Developmental Cell. - 1534-5807. ; 58:17, s. 9-1609
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Translational regulation impacts both pluripotency maintenance and cell differentiation. To what degree the ribosome exerts control over this process remains unanswered. Accumulating evidence has demonstrated heterogeneity in ribosome composition in various organisms. 2′-O-methylation (2′-O-me) of rRNA represents an important source of heterogeneity, where site-specific alteration of methylation levels can modulate translation. Here, we examine changes in rRNA 2′-O-me during mouse brain development and tri-lineage differentiation of human embryonic stem cells (hESCs). We find distinct alterations between brain regions, as well as clear dynamics during cortex development and germ layer differentiation. We identify a methylation site impacting neuronal differentiation. Modulation of its methylation levels affects ribosome association of the fragile X mental retardation protein (FMRP) and is accompanied by an altered translation of WNT pathway-related mRNAs. Together, these data identify ribosome heterogeneity through rRNA 2′-O-me during early development and differentiation and suggest a direct role for ribosomes in regulating translation during cell fate acquisition.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- 2′-O-methylation
- brain development
- cell fate
- development
- differentiation
- human embryonic stem cells
- neurogenesis
- ribosome
- RNA modifications
- translation
- translation programs
Publication and Content Type
- art (subject category)
- ref (subject category)
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Häfner, Sophia J ...
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Jansson, Martin ...
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Altinel, Kübra
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Andersen, Kasper ...
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Abay-Nørgaard, Z ...
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Ménard, Patrice
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Fontenas, Martin
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Sørensen, Daniel ...
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Gay, David M.
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Arendrup, Freder ...
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Tehler, Disa
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Krogh, Nicolai
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Nielsen, Henrik
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Kraushar, Matthe ...
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Kirkeby, Agnete
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Lund, Anders H.
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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Developmental Ce ...
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Lund University