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Coronary Plaque in People With HIV vs Non-HIV Asymptomatic Community and Symptomatic Higher-Risk Populations

Karady, Julia (author)
Semmelweis University,Massachusetts General Hospital
Lu, Michael T. (author)
Massachusetts General Hospital
Bergström, Göran (author)
Sahlgrenska Academy,Sahlgrenska University Hospital
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Mayrhofer, Thomas (author)
Massachusetts General Hospital,University of Applied Sciences Stralsund
Taron, Jana (author)
University Medical Center Freiburg,Massachusetts General Hospital
Foldyna, Borek (author)
Massachusetts General Hospital
Paradis, Kayla (author)
Massachusetts General Hospital
McCallum, Sara (author)
Massachusetts General Hospital
Aberg, Judith A. (author)
Icahn School of Medicine at Mount Sinai
Currier, Judith S. (author)
University of California, Los Angeles
Fitch, Kathleen V. (author)
Massachusetts General Hospital
Fulda, Evelynne S. (author)
Massachusetts General Hospital
Bloomfield, Gerald S. (author)
Duke Clinical Research Institute (DCRI)
Overton, Edgar T. (author)
Lind, Lars (author)
Uppsala University
Östgren, Carl Johan (author)
Linköping University
Elvstam, Olof (author)
Lund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups,Växjö Central Hospital
Söderberg, Stefan (author)
Umeå University
Jernberg, Tomas (author)
Danderyd Hospital
Pepe, Rosalie (author)
Cooper University Hospital, Camden
Dubé, Michael P. (author)
University of Southern California
Mushatt, David (author)
Tulane University School of Medicine
Fichtenbaum, Carl J. (author)
University of Cincinnati
Malvestutto, Carlos (author)
Ohio State University
Zanni, Markella V. (author)
Massachusetts General Hospital
Hoffmann, Udo (author)
Massachusetts General Hospital
Ribaudo, Heather (author)
Grinspoon, Steven K. (author)
Massachusetts General Hospital
Douglas, Pamela S. (author)
Duke Clinical Research Institute (DCRI)
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 (creator_code:org_t)
2024
2024
English.
In: JACC: Advances. - 2772-963X. ; 3:6
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Background: People with HIV (PWH) have a high burden of coronary plaques; however, the comparison to people without known HIV (PwoH) needs clarification. Objectives: The purpose of this study was to determine coronary plaque burden/phenotype in PWH vs PwoH. Methods: Nonstatin using participants from 3 contemporary populations without known coronary plaques with coronary CT were compared: the REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV) studying PWH without cardiovascular symptoms at low-to-moderate risk (n = 755); the SCAPIS (Swedish Cardiopulmonary Bioimage Study) of asymptomatic community PwoH at low-to-intermediate cardiovascular risk (n = 23,558); and the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) of stable chest pain PwoH (n = 2,291). The coronary plaque prevalence on coronary CT was compared, and comparisons were stratified by 10-year atherosclerotic cardiovascular disease (ASCVD) risk, age, and coronary artery calcium (CAC) presence. Results: Compared to SCAPIS and PROMISE PwoH, REPRIEVE PWH were younger (50.8 ± 5.8 vs 57.3 ± 4.3 and 60.0 ± 8.0 years; P < 0.001) and had lower ASCVD risk (5.0% ± 3.2% vs 6.0% ± 5.3% and 13.5% ± 11.0%; P < 0.001). More PWH had plaque compared to the asymptomatic cohort (48.5% vs 40.3%; P < 0.001). When stratified by ASCVD risk, PWH had more plaque compared to SCAPIS and a similar prevalence of plaque compared to PROMISE. CAC = 0 was more prevalent in PWH (REPRIEVE 65.2%; SCAPIS 61.6%; PROMISE 49.6%); among CAC = 0, plaque was more prevalent in PWH compared to the PwoH cohorts (REPRIEVE 20.8%; SCAPIS 5.4%; PROMISE 12.3%, P < 0.001). Conclusions: Asymptomatic PWH in REPRIEVE had more plaque than asymptomatic PwoH in SCAPIS but had similar prevalence to a higher-risk stable chest pain cohort in PROMISE. In PWH, CAC = 0 does not reliably exclude plaque.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Keyword

asymptomatic community cohort
cardiovascular disease
coronary CT angiography
coronary plaque
people with HIV
stable chest pain

Publication and Content Type

art (subject category)
ref (subject category)

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