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  • Karady, JuliaCardiovascular Imaging Research Center, Massachusetts General Hospital & Harvard Medical School, MA, Boston, United States; Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary (author)

Coronary plaque in people with HIV vs non-HIV asymptomatic community and symptomatic higher-risk populations

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • Elsevier,2024
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-228064
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-228064URI
  • https://doi.org/10.1016/j.jacadv.2024.100968DOI
  • https://lup.lub.lu.se/record/f0f696ce-f40b-4edc-a374-a09a1071e244URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: People with HIV (PWH) have a high burden of coronary plaques; however, the comparison to people without known HIV (PwoH) needs clarification.Objectives: The purpose of this study was to determine coronary plaque burden/phenotype in PWH vs PwoH.Methods: Nonstatin using participants from 3 contemporary populations without known coronary plaques with coronary CT were compared: the REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV) studying PWH without cardiovascular symptoms at low-to-moderate risk (n = 755); the SCAPIS (Swedish Cardiopulmonary Bioimage Study) of asymptomatic community PwoH at low-to-intermediate cardiovascular risk (n = 23,558); and the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) of stable chest pain PwoH (n = 2,291). The coronary plaque prevalence on coronary CT was compared, and comparisons were stratified by 10-year atherosclerotic cardiovascular disease (ASCVD) risk, age, and coronary artery calcium (CAC) presence.Results: Compared to SCAPIS and PROMISE PwoH, REPRIEVE PWH were younger (50.8 ± 5.8 vs 57.3 ± 4.3 and 60.0 ± 8.0 years; P < 0.001) and had lower ASCVD risk (5.0% ± 3.2% vs 6.0% ± 5.3% and 13.5% ± 11.0%; P < 0.001). More PWH had plaque compared to the asymptomatic cohort (48.5% vs 40.3%; P < 0.001). When stratified by ASCVD risk, PWH had more plaque compared to SCAPIS and a similar prevalence of plaque compared to PROMISE. CAC = 0 was more prevalent in PWH (REPRIEVE 65.2%; SCAPIS 61.6%; PROMISE 49.6%); among CAC = 0, plaque was more prevalent in PWH compared to the PwoH cohorts (REPRIEVE 20.8%; SCAPIS 5.4%; PROMISE 12.3%, P < 0.001).Conclusions: Asymptomatic PWH in REPRIEVE had more plaque than asymptomatic PwoH in SCAPIS but had similar prevalence to a higher-risk stable chest pain cohort in PROMISE. In PWH, CAC = 0 does not reliably exclude plaque.

Subject headings and genre

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  • Lu, Michael T.Cardiovascular Imaging Research Center, Massachusetts General Hospital & Harvard Medical School, MA, Boston, United States (author)
  • Bergström, GöranDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Clinical Physiology, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden (author)
  • Mayrhofer, ThomasCardiovascular Imaging Research Center, Massachusetts General Hospital & Harvard Medical School, MA, Boston, United States; School of Business Studies, Stralsund University of Applied Sciences, Stralsund, Germany (author)
  • Taron, JanaCardiovascular Imaging Research Center, Massachusetts General Hospital & Harvard Medical School, MA, Boston, United States; Faculty of Medicine, Department of Radiology, Medical Center-University of Freiburg, University of Freiburg, Freiburg im Breisgau, Germany (author)
  • Foldyna, BorekCardiovascular Imaging Research Center, Massachusetts General Hospital & Harvard Medical School, MA, Boston, United States (author)
  • Paradis, KaylaCardiovascular Imaging Research Center, Massachusetts General Hospital & Harvard Medical School, MA, Boston, United States (author)
  • McCallum, SaraMetabolism Unit, Massachusetts General Hospital & Harvard Medical School, MA, Boston, United States (author)
  • Aberg, Judith A.Department of Medicine, Icahn School of Medicine at Mount Sinai, NY, New York, United States (author)
  • Söderberg, StefanUmeå universitet,Umeå University,Department of Medicine, University of California at Los Angeles, CA, Los Angeles, United States,Avdelningen för medicin,Duke Clinical Research Institute, Duke University School of Medicine, NC, Durham, United States(Swepub:umu)stso0001 (author)
  • Fitch, Kathleen V.Metabolism Unit, Massachusetts General Hospital & Harvard Medical School, MA, Boston, United States (author)
  • Fulda, Evelynne S.Metabolism Unit, Massachusetts General Hospital & Harvard Medical School, MA, Boston, United States (author)
  • Bloomfield, Gerald S.Duke Clinical Research Institute, Duke University School of Medicine, NC, Durham, United States,Duke Clinical Research Institute (DCRI) (author)
  • Overton, Edgar T.Division of Infectious Diseases, University of Alabama at Birmingham, AL, Birmingham, United States (author)
  • Lind, LarsUppsala University,Division of Clinical Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden (author)
  • Östgren, Carl JohanLinköping University,Faculty of Medicine and Health Sciences, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden; Center of Medical Image Science and Visualization, Linköping University, Linköping, Sweden (author)
  • Elvstam, OlofLund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups,Department of Translational Medicine, Lund University, Malmö, Sweden; Department of Infectious Diseases, Växjö Central Hospital, Växjö, Sweden(Swepub:lu)ol8873el (author)
  • Söderberg, StefanUmeå universitet,Avdelningen för medicin,Duke Clinical Research Institute (DCRI)(Swepub:umu)stso0001 (author)
  • Jernberg, TomasDivision of Cardiovascular Medicine, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institute, Stockholm, Sweden (author)
  • Pepe, RosalieCooper University Hospital, NJ, Camden, United States (author)
  • Dubé, Michael P.Division of Infectious Diseases, University of Southern California Keck School of Medicine, CA, Los Angeles, United States (author)
  • Mushatt, DavidSection of Infectious Disease, Tulane School of Medicine, LA, New Orleans, United States,Tulane University School of Medicine (author)
  • Fichtenbaum, Carl J.Division of Infectious Diseases, University of Cincinnati, OH, Cincinnati, United States (author)
  • Malvestutto, CarlosDivision of Infectious Diseases, The Ohio State University Wexner Medical Center, OH, Columbus, United States (author)
  • Zanni, Markella V.Metabolism Unit, Massachusetts General Hospital & Harvard Medical School, MA, Boston, United States (author)
  • Hoffmann, UdoCardiovascular Imaging Research Center, Massachusetts General Hospital & Harvard Medical School, MA, Boston, United States; Innovative Imaging Consulting LLC, MA, Boston, United States (author)
  • Ribaudo, HeatherCenter for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, MA, Boston, United States (author)
  • Grinspoon, Steven K.Metabolism Unit, Massachusetts General Hospital & Harvard Medical School, MA, Boston, United States (author)
  • Douglas, Pamela S.Duke Clinical Research Institute, Duke University School of Medicine, NC, Durham, United States (author)
  • Cardiovascular Imaging Research Center, Massachusetts General Hospital & Harvard Medical School, MA, Boston, United States; Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, HungaryCardiovascular Imaging Research Center, Massachusetts General Hospital & Harvard Medical School, MA, Boston, United States (creator_code:org_t)

Related titles

  • In:JACC: Advances: Elsevier3:62772-963X

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