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- Hjelmgren, Jonas (author)
Estimating the value of novel interventions for Parkinson's disease: An early decision-making model with application to dopamine cell replacement.
- Article/chapterEnglish2006
Publisher, publication year, extent ...
- Elsevier BV,2006
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:f26aa2f5-4379-4568-a9ad-b687457477ad
- https://lup.lub.lu.se/record/158123URI
- https://doi.org/10.1016/j.parkreldis.2006.04.006DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- A long-term cost-effectiveness model for early decision-making and estimation of outcomes of novel therapeutic procedures for Parkinson's disease (PD) was developed based on the Hoehn and Yahr (HY) stages of PD. Results provided support for model validity. Model application to a future dopamine cell replacement therapy indicated long-term cost offsets and gains in quality-adjusted life years (QALYs) in early onset PD (HY III-IV), as compared to standard drug therapy. The maximum price premium (i.e., profit or compensation for developmental costs) for the intervention to remain cost-effective was estimated to EURO12000-64000 according to cost-per-QALY thresholds of EURO38000-70000 and depending on whether all or only medical direct costs are considered. The study illustrates the value of early health economic modeling and the described model shows promise as a means to estimate outcomes and aid decision-making regarding novel interventions for PD. (c) 2006 Elsevier Ltd. All rights reserved.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
- cell
- therapy
- cost-effectiveness
- Parkinson's disease
- outcomes
- modeling
Added entries (persons, corporate bodies, meetings, titles ...)
- Ghatnekar, Ola (author)
- Reimer, JanLund University,Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine(Swepub:lu)neur-jre (author)
- Grabowski, MartinLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)neur-mgr (author)
- Lindvall, OlleLund University,Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine(Swepub:lu)neur-oli (author)
- Persson, Ulf (author)
- Hagell, PeterLund University,Lunds universitet,Institutionen för hälsovetenskaper,Medicinska fakulteten,Department of Health Sciences,Faculty of Medicine(Swepub:lu)neur-pha (author)
- Wallenberg Neurocentrum, LundMedicinska fakulteten (creator_code:org_t)
Related titles
- In:Parkinsonism & Related Disorders: Elsevier BV12:7, s. 443-4521873-51261353-8020
Internet link
- https://portal.research.lu.se/files/2679429/625490.pdfFULLTEXT
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16798054&dopt=AbstractFULLTEXT
- http://dx.doi.org/10.1016/j.parkreldis.2006.04.006FULLTEXT
- https://lup.lub.lu.se/search/files/2679429/625490.pdf
- https://lup.lub.lu.se/record/158123
- https://doi.org/10.1016/j.parkreldis.2006.04.006
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