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  • Breiteneder, HeimoMedical University of Vienna (author)

Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-09-30
  • Wiley,2020
  • 30 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:f27d2090-e4da-4608-aed6-b7764e458789
  • https://lup.lub.lu.se/record/f27d2090-e4da-4608-aed6-b7764e458789URI
  • https://doi.org/10.1111/all.14582DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:for swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Modern health care requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the area of personalized medicine, disease phenotyping and endotyping, and the development and application of reliable biomarkers. A detailed clinical history and physical examination followed by the detection of IgE immunoreactivity against specific allergens still represents the state of the art. However, nowadays, further emphasis focuses on the optimization of diagnostic and therapeutic standards and a large number of studies have been investigating the biomarkers of allergic diseases, including asthma, atopic dermatitis, allergic rhinitis, food allergy, urticaria and anaphylaxis. Various biomarkers have been developed by omics technologies, some of which lead to a better classification of distinct phenotypes or endotypes. The introduction of biologicals to clinical practice increases the need for biomarkers for patient selection, prediction of outcomes and monitoring, to allow for an adequate choice of the duration of these costly and long-lasting therapies. Escalating healthcare costs together with questions about the efficacy of the current management of allergic diseases require further development of a biomarker-driven approach. Here, we review biomarkers in diagnosis and treatment of asthma, atopic dermatitis, allergic rhinitis, viral infections, chronic rhinosinusitis, food allergy, drug hypersensitivity and allergen immunotherapy with a special emphasis on specific IgE, the microbiome and the epithelial barrier. In addition, EAACI guidelines on biologicals are discussed within the perspective of biomarkers.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Peng, Ya QiChristine Kühne Center for Allergy Research and Education (CK-CARE),University of Zurich (author)
  • Agache, IoanaTransylvania University Brasov (author)
  • Diamant, ZuzanaLund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,University Medical Center Groningen,Charles University in Prague(Swepub:lu)med-zdt (author)
  • Eiwegger, ThomasUniversity of Toronto,Hospital for Sick Children, Toronto (author)
  • Fokkens, Wytske J.Academic Medical Center of University of Amsterdam (AMC) (author)
  • Traidl-Hoffmann, ClaudiaTechnical University of Munich,Christine Kühne Center for Allergy Research and Education (CK-CARE),Helmholtz Zentrum München (author)
  • Nadeau, KariStanford University (author)
  • O'Hehir, Robyn E.Alfred Health,Monash University (author)
  • O'Mahony, LiamUniversity College Cork (author)
  • Pfaar, OliverUniversity Hospital Giessen and Marburg (author)
  • Torres, Maria J.Hospital Regional de Málaga (author)
  • Wang, De YunNational University of Singapore (author)
  • Zhang, LuoBeijing Tongren Hospital (author)
  • Akdis, Cezmi A.University of Zurich,Christine Kühne Center for Allergy Research and Education (CK-CARE) (author)
  • Medical University of ViennaChristine Kühne Center for Allergy Research and Education (CK-CARE) (creator_code:org_t)

Related titles

  • In:Allergy: European Journal of Allergy and Clinical Immunology: Wiley75:12, s. 3039-30680105-4538
  • In:Allergy: Wiley75:12, s. 3039-30681398-9995

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