Glutathione transferase activity in human vessels and in cultured arterial smooth muscle cells

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MARC

Pessah-Rasmussen, HLund University,Lunds universitet,Rehabiliteringsmedicin,Forskargrupper vid Lunds universitet,Rehabilitation medicine,Lund University Research Groups (author)

Glutathione transferase activity in human vessels and in cultured arterial smooth muscle cells

Article/chapterEnglish1993

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1993

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LIBRIS-ID:oai:lup.lub.lu.se:f3ba5f9f-c6a1-49c9-81cc-f133867e7c55
https://lup.lub.lu.se/record/f3ba5f9f-c6a1-49c9-81cc-f133867e7c55URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

Glutathione transferases play an important role in the detoxification of many different endogeneous and exogenous compounds such as metabolites of polycyclic aromatic hydrocarbons (PAH) of cigarette tar. There is evidence that PAH may be atherogenic. The glutathione transferase activity towards trans-stilbene oxide (GST-tSBO) can be separated in blood in GST-positive and GST-negative phenotypes. We have previously suggested that the GST-negative phenotype may be associated with a higher morbidity in intermittent claudication among middle aged smokers. In the present study, GST-tSBO could easily be measured in human, rabbit and bovine arterial smooth muscle cells (SMC) in culture. The level of GST-tSBO was higher in rabbit than in bovine SMC. It was stable in bovine SMC during 5 cell passages and it could be induced twofold by long-time incubation with dimethylsulfoxide-soluble particulate matter from cigarette smoke or 3,4-benzo(a)pyrene. There was a positive correlation between the level of GST-tSBO in blood and in "healthy" arterial and venous tissue from individuals operated with coronary bypass. The enzyme levels in arterial tissue were lower than in venous tissue. GST-tSBO in atherosclerotic segments of human arteries was lower than in "healthy" segments from the same artery. These findings suggest that the arterial wall may have a low defense against toxic compounds that may decrease further as atherosclerosis proceeds. It is concluded that SMC are suitable for the study of the effects of PAH in relation to GST-tSBO and that the enzyme activity in blood will reflect the individual GST-tSBO phenotype also in vascular tissues.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
Adult
Animals
Arteriosclerosis
Cattle
Cells, Cultured
Female
Glutathione Transferase
Humans
In Vitro Techniques
Male
Middle Aged
Muscle, Smooth, Vascular
Phenotype
Polycyclic Compounds
Rabbits
Smoking
Stilbenes
Journal Article
Research Support, Non-U.S. Gov't

Added entries (persons, corporate bodies, meetings, titles ...)

Seidegård, JLund University,Lunds universitet,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)extLU-263 (author)
Stavenow, L. (author)
Solem, J OLund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)thor-jso (author)
Lindblad, BLund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups(Swepub:lu)kir-bli (author)
Xu, C BLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-cxu (author)
RehabiliteringsmedicinForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

In:International Angiology12:4, s. 54-3480392-9590

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