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  • Landolfo, C.Catholic University of Leuven,Policlinico Universitario Agostino Gemelli (författare)

Benign descriptors and ADNEX in two-step strategy to estimate risk of malignancy in ovarian tumors : retrospective validation on IOTA 5 multicenter cohort

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • 2023-01-12
  • Wiley,2023

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:f415a911-6929-42c5-9de0-8b71b3f05792
  • https://lup.lub.lu.se/record/f415a911-6929-42c5-9de0-8b71b3f05792URI
  • https://doi.org/10.1002/uog.26080DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:151821790URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Objective: Previous work suggested that the ultrasound-based benign Simple Descriptors can reliably exclude malignancy in a large proportion of women presenting with an adnexal mass. We aim to validate a modified version of the Benign Simple Descriptors (BD), and we introduce a two-step strategy to estimate the risk of malignancy: if the BDs do not apply, the ADNEX model is used to estimate the risk of malignancy. Methods: This is a retrospective analysis using the data from the 2-year interim analysis of the IOTA5 study, in which consecutive patients with at least one adnexal mass were recruited irrespective of subsequent management (conservative or surgery). The main outcome was classification of tumors as benign or malignant, based on histology or on clinical and ultrasound information during one year of follow-up. Multiple imputation was used when outcome based on follow-up was uncertain according to predefined criteria. Results: 8519 patients were recruited at 36 centers between 2012 and 2015. We included all masses that were not already in follow-up at recruitment from 17 centers with good quality surgical and follow-up data, leaving 4905 patients for statistical analysis. 3441 (70%) tumors were benign, 978 (20%) malignant, and 486 (10%) uncertain. The BDs were applicable in 1798/4905 (37%) tumors, and 1786 (99.3%) of these were benign. The two-step strategy based on ADNEX without CA125 had an area under the receiver operating characteristic curve (AUC) of 0.94 (95% CI, 0.91-0.95). The risk of malignancy was slightly underestimated, but calibration varied between centers. A sensitivity analysis in which we expanded the definition of uncertain outcome resulted in 1419 (29%) tumors with uncertain outcome and an AUC of the two-step strategy without CA125 of 0.93 (95% CI, 0.91-0.95). Conclusion: A large proportion of adnexal masses can be classified as benign by the BDs. For the remaining masses the ADNEX model can be used to estimate the risk of malignancy. This two-step strategy is convenient for clinical use.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Bourne, T.University Hospitals Leuven,Catholic University of Leuven,Queen Charlotte's and Chelsea Hospital (författare)
  • Froyman, W.University Hospitals Leuven,Catholic University of Leuven (författare)
  • Van Calster, B.Catholic University of Leuven,Leiden University Medical Centre (författare)
  • Ceusters, J.Catholic University of Leuven (författare)
  • Testa, A. C.Policlinico Universitario Agostino Gemelli,Catholic University of the Sacred Heart, Rome,Medical University of Lublin,Catholic University of Leuven (författare)
  • Wynants, L.Maastricht University,Catholic University of Leuven (författare)
  • Sladkevicius, P.Lund University,Lunds universitet,Obstetrisk, gynekologisk och prenatal ultraljudsdiagnostik,Forskargrupper vid Lunds universitet,Obstetric, Gynaecological and Prenatal Ultrasound Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)obst-psl (författare)
  • Van Holsbeke, C.Hospital Oost-Limburg,Istituto Nazionale dei Tumori (författare)
  • Domali, E.National and Kapodistrian University of Athens (författare)
  • Fruscio, R.University of Milano-Bicocca (författare)
  • Epstein, E.Karolinska Institutet,Karolinska Institute,Stockholm South General Hospital,University of Florence(Swepub:lu)obst-eep (författare)
  • Franchi, D.European Institute of Oncology (författare)
  • Kudla, M. J.Medical University of Silesia (författare)
  • Chiappa, V.Istituto Nazionale dei Tumori (författare)
  • Jokubkiene, L.Lund University,Lunds universitet,Urogynekologi och reproduktionsfarmakologi,Forskargrupper vid Lunds universitet,Urogynaecology and Reproductive Pharmacology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)obst-ljo (författare)
  • Leone, F. P.G.Luigi Sacco University Hospital (författare)
  • Buonomo, F.Burlo Garofolo Pediatric Institute (författare)
  • Coccia, M. E.University of Florence (författare)
  • Guerriero, S.Policlinico Universitario Agostino Gemelli,Catholic University of the Sacred Heart, Rome (författare)
  • Deo, N.Whipps Cross University Hospital (författare)
  • Jokubkiene, L.Lund University,Lunds universitet,Urogynekologi och reproduktionsfarmakologi,Forskargrupper vid Lunds universitet,Urogynaecology and Reproductive Pharmacology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)obst-ljo (författare)
  • Savelli, L.St. Orsola-Malpighi University Hospital (författare)
  • Fischerova, D.General University Hospital in Prague (författare)
  • Czekierdowski, A.Medical University of Lublin (författare)
  • Kaijser, J.Ikazia Hospital (författare)
  • Coosemans, A.Catholic University of Leuven (författare)
  • Scambia, G.Policlinico Universitario Agostino Gemelli,Catholic University of the Sacred Heart, Rome (författare)
  • Vergote, I.Catholic University of Leuven,University Hospitals Leuven (författare)
  • Timmerman, D.Catholic University of Leuven,University Hospitals Leuven (författare)
  • Valentin, L.Lund University,Lunds universitet,Obstetrisk, gynekologisk och prenatal ultraljudsdiagnostik,Forskargrupper vid Lunds universitet,Obstetric, Gynaecological and Prenatal Ultrasound Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)obst-lva (författare)
  • Catholic University of LeuvenPoliclinico Universitario Agostino Gemelli (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Ultrasound in Obstetrics and Gynecology: Wiley61:2, s. 231-2420960-76921469-0705

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