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Biological use infl...
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Karpouzas, George AthanasiosInternal Medicine - Rheumatology, CA, Torrance, United States; Harbor-UCLA Medical Center, Rheumatology, CA, Torrance, United States
(författare)
Biological use influences the impact of inflammation on risk of major adverse cardiovascular events in rheumatoid arthritis
- Artikel/kapitelEngelska2024
Förlag, utgivningsår, omfång ...
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BMJ Publishing Group Ltd,2024
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-228118
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-228118URI
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https://doi.org/10.1136/rmdopen-2024-004546DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Objectives: Chronic inflammation promotes cardiovascular risk in rheumatoid arthritis (RA). Biological disease-modifying antirheumatic drugs (bDMARDs) improve disease activity and cardiovascular disease outcomes. We explored whether bDMARDs influence the impact of disease activity and inflammatory markers on long-term cardiovascular risk in RA.Methods: We studied 4370 participants without cardiovascular disease in a 10-country observational cohort of patients with RA. Endpoints were (1) major adverse cardiovascular events (MACE) encompassing myocardial infarction, stroke and cardiovascular death; and (2) any ischaemic cardiovascular events (iCVE) including MACE plus revascularisation, angina, transient ischaemic attack and peripheral arterial disease.Results: Over 26 534 patient-years, 239 MACE and 362 iCVE occurred. The interaction between 28-joint Disease Activity Score with C-reactive protein (DAS28-CRP) and bDMARD use was significant for MACE (p=0.017), suggesting the effect of DAS28-CRP on MACE risk differed among bDMARD users (n=515) and non-users (n=3855). DAS28-CRP (per unit increase) is associated with MACE risk in bDMARD non-users (HR 1.21 (95% CI 1.07 to 1.37)) but not users (HR 0.69 (95% CI 0.40 to 1.20)). The interaction between CRP (per log unit increase) and bDMARD use was also significant for MACE (p=0.011). CRP associated with MACE risk in bDMARD non-users (HR 1.16 (95% CI 1.04 to 1.30)), but not users (HR 0.65 (95% CI 0.36 to 1.17)). No interaction was observed between bDMARD use and DAS28-CRP (p=0.167) or CRP (p=0.237) for iCVE risk.Conclusions: RA activity and inflammatory markers associated with risk of MACE in bDMARD non-users but not users suggesting the possibility of biological-specific benefits locally on arterial wall independently of effects on systemic inflammation.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Ormseth, Sarah R.CA, Torrance, United States
(författare)
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van Riel, Piet Leonardus Cornelis MariaIQ Healthcare, Radboud University, Gelderland, Nijmegen, Netherlands; Bernhoven Hospital Location Oss, Rheumatology, Oss, Netherlands
(författare)
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Gonzalez-Gay, Miguel A.Rheumatology, Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain; IIS-Fundacion Jimenez Diaz, Madrid, Spain
(författare)
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Corrales, AlfonsoHospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain
(författare)
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Rantapää-Dahlqvist, SolbrittUmeå universitet,Reumatologi(Swepub:umu)sora0001
(författare)
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Sfikakis, Petros P.First Dept. of Propedeutic Medicine, University of Athens, Attica, Athens, Greece
(författare)
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Dessein, PatrickSchool of Physiology, University of the Witwatersrand Johannesburg, Johannesburg, South Africa
(författare)
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Tsang, LindaVrije Universiteit Brussel, Belgium
(författare)
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Hitchon, CarolUniversity of Manitoba, Rheumatology, MB, Winnipeg, Canada
(författare)
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El-Gabalawy, HaniDepartment of Internal Medicine, University of Manitoba, MB, Winnipeg, Canada
(författare)
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Pascual-Ramos, VirginiaImmunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
(författare)
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Contreras-Yáñez, IrazúDepartment of Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, Mexico
(författare)
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Colunga-Pedraza, Iris J.Hospital Universitario Dr José Eleuterio González, Rheumatology, Nuevo León, Monterrey, Mexico
(författare)
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Galarza-Delgado, Dionicio AngelHospital Universitario Dr Jose Eleuterio Gonzalez, Rheumatology, Nuevo León, Monterrey, Mexico
(författare)
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Azpiri-Lopez, Jose RamonHospital Universitario Dr José Eleuterio González, Nuevo León, Monterrey, Mexico
(författare)
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Semb, Anne GreteRheumatology and Research, Diakonhjemmet Hospital, Oslo, Norway
(författare)
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Misra, Durga PrasannaClinical Immunology and Rheumatology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Uttar Pradesh, Lucknow, India
(författare)
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Hauge, Ellen-MargretheDepartment of Joint and Connective Tissue Diseases, Aarhus Universitetshospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus Universitet, Aarhus, Denmark
(författare)
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Kitas, GeorgeDepartment of Rheumatology, Dudley Group NHS Foundation Trust, West Midlands, Dudley, United Kingdom
(författare)
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Internal Medicine - Rheumatology, CA, Torrance, United States; Harbor-UCLA Medical Center, Rheumatology, CA, Torrance, United StatesCA, Torrance, United States
(creator_code:org_t)
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Ingår i:RMD Open: BMJ Publishing Group Ltd10:32056-5933
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Karpouzas, Georg ...
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Ormseth, Sarah R ...
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van Riel, Piet L ...
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Gonzalez-Gay, Mi ...
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Corrales, Alfons ...
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Rantapää-Dahlqvi ...
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visa fler...
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Sfikakis, Petros ...
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Dessein, Patrick
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Tsang, Linda
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Hitchon, Carol
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El-Gabalawy, Han ...
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Pascual-Ramos, V ...
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Contreras-Yáñez, ...
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Colunga-Pedraza, ...
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Galarza-Delgado, ...
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Azpiri-Lopez, Jo ...
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Semb, Anne Grete
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Misra, Durga Pra ...
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Hauge, Ellen-Mar ...
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Kitas, George
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