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  • Volarevic, Vladislav (author)

Gal-3 regulates the capacity of dendritic cells to promote NKT-cell-induced liver injury

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • 2014-11-27
  • Wiley,2015

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:f5068278-3b81-4368-b4e4-1775e9e20eff
  • https://lup.lub.lu.se/record/5160213URI
  • https://doi.org/10.1002/eji.201444849DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Galectin-3 (Gal-3), an endogenous lectin, exhibits ro- and anti-inflammatory effects in various disease conditions. In order to explore the role of Gal-3 in KT-cell-dependent pathology, we induced hepatitis in C57BL/6WT and al-3-deficient mice by using specific ligand for KT cells: alpha-galactosylceramide, glycolipid Ag presented by CD1d. The injection of alpha-galactosylceramide significantly enhanced expression of Gal-3 in liver NKT and dendritic cells (DCs). Genetic deletion or selective inhibition of Gal-3 (induced by Gal-3-inhibitor TD139) abrogated the susceptibility to NKT-cell-dependent hepatitis. Blood levels of pro-inflammatory cytokines (TNF-alpha-, IFN-gamma, IL-12) and their production by liver DCs and NKT cells were also downregulated. Genetic deletion or selective inhibition of Gal-3 alleviated influx of inflammatory CD11c(+) CD11b(+) DCs in the liver and favored tolerogenic phenotype and IL-10 production of liver NKT and DCs. Deletion of Gal-3 attenuated the capacity of DCs to support liver damage in the passive transfer experiments and to produce pro-inflammatory cytokines in vitro. Gal-3-deficient DCs failed to optimally stimulate production of pro-inflammatory cytokines in NKT cells, in vitro and in vivo. In conclusion, Gal-3 regulates the capacity of DCs to support NKT-cell-mediated liver injury, playing an important pro-inflammatory role in acute liver injury.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Markovic, Bojana Simovic (author)
  • Bojic, Sanja (author)
  • Stojanovic, Maja (author)
  • Nilsson, UlfLund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)ok2-uni (author)
  • Leffler, HakonLund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)mmb-hle (author)
  • Besra, Gurdyal S. (author)
  • Arsenijevic, Nebojsa (author)
  • Paunovic, Verica (author)
  • Trajkovic, Vladimir (author)
  • Lukic, Miodrag L. (author)
  • Centrum för analys och syntesKemiska institutionen (creator_code:org_t)

Related titles

  • In:European Journal of Immunology: Wiley45:2, s. 531-5431521-41410014-2980

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