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Mediterranean Diet and Telomere Length : A Systematic Review and Meta-Analysis
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- Canudas, Silvia (author)
- Carlos III Health Institute,Rovira i Virgili University (URV)
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- Becerra-Tomas, Nerea (author)
- Carlos III Health Institute,Rovira i Virgili University (URV),University of Valencia
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- Hernandez-Alonso, Pablo (author)
- University of Valencia,Hospitales Regional Universitario y Virgen de la Victoria de Málaga,Rovira i Virgili University (URV),Carlos III Health Institute
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- Galie, Serena (author)
- Carlos III Health Institute,Rovira i Virgili University (URV)
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- Leung, Cindy (author)
- University of Michigan
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- Crous-Bou, Marta (author)
- Harvard University,Carlos III Health Institute
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- De Vivo, Immaculata (author)
- Harvard University,Harvard Medical School
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- Gao, Yawen (author)
- Harvard University
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- Gu, Yian (author)
- Columbia University
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- Meinila, Jelena (author)
- Folkhälsan Research Center
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Milte, Catherine (author)
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- Garcia-Calzon, Sonia (author)
- Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups
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- Marti, Amelia (author)
- Carlos III Health Institute,University of Navarra
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- Boccardi, Virginia (author)
- Second University of Napels
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- Ventura-Marra, Melissa (author)
- University of West Virginia
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- Salas-Salvado, Jordi (author)
- Carlos III Health Institute,Rovira i Virgili University (URV)
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English 11 s.
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In: Advances in Nutrition. - : Elsevier BV. - 2161-8313. ; 11:6, s. 1544-1554
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http://dx.doi.org/10...
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Abstract
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- Accelerated telomere shortening has been associated with several age-related diseases and/or decreased lifespan in humans. The Mediterranean diet (MedDiet) is considered to be 1 of the most recognized diets for disease prevention and healthy aging, partially due to its demonstrated anti-inflammatory and antioxidative properties which may impact on telomere length (TL). The aim of this meta-analysis was to determine the associations between MedDiet adherence and TL maintenance. MEDLINE-PubMed and Cochrane databases were searched up to December 2018 for studies evaluating the association between MedDiet adherence and TL in blood cells. Two reviewers, working independently, screened all titles and abstracts to identify studies that met the inclusion criteria [cross-sectional, case-control, and prospective cohort studies and randomized clinical trials (RCTs) published in English and excluded nonoriginal articles]. Data were pooled by the generic inverse variance method using the random effects model and expressed as standardized mean difference (SMD). Heterogeneity was identified using the Cochran Q test and quantified by the I2 statistic. A total of 8 original cross-sectional studies were included for the quantitative meta-analysis, comprising a total of 13,733 participants from 5 countries. A positive association between adherence to the MedDiet and TL was observed in all meta-analyses, with the exception of those conducted only in men: SMD (95% CI) of 0.130 (0.029; 0.231) for all subjects, 0.078 (0.005; 0.152) for women, and 0.095 (-0.005; 0.195) for men. Only 1 prospective cohort study and 1 RCT were identified, therefore, we could not undertake a meta-analysis for these study designs. The present meta-analysis of cross-sectional studies demonstrates that higher MedDiet adherence is associated with longer TL. At the same time, larger and high-quality prospective studies and clinical trials are warranted to confirm this association.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- accelerated telomere shortening
- age-associated diseases
- dietary pattern
- healthy aging
- Mediterranean diet
- telomere length
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- By the author/editor
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Canudas, Silvia
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Becerra-Tomas, N ...
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Hernandez-Alonso ...
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Galie, Serena
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Leung, Cindy
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Crous-Bou, Marta
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De Vivo, Immacul ...
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Gao, Yawen
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Gu, Yian
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Meinila, Jelena
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Milte, Catherine
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Garcia-Calzon, S ...
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Marti, Amelia
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Boccardi, Virgin ...
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Ventura-Marra, M ...
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Salas-Salvado, J ...
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Advances in Nutr ...
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Lund University