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Sökning: WFRF:(Heuzey Jean Yves Le) > (2015-2017) > Sex-specific outcom...

  • Barra, SérgioPapworth Hospital (författare)

Sex-specific outcomes with addition of defibrillation to resynchronisation therapy in patients with heart failure

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • 2017-01-19
  • BMJ,2017

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:f5b138ec-2ceb-4488-8aec-aea8c99438ff
  • https://lup.lub.lu.se/record/f5b138ec-2ceb-4488-8aec-aea8c99438ffURI
  • https://doi.org/10.1136/heartjnl-2016-310677DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Objective Among primary prevention patients with heart failure receiving cardiac resynchronisation therapy (CRT), the impact of additional implantable cardioverter defibrillator (ICD) treatment on outcomes and its interaction with sex remains uncertain. We aim to assess whether the addition of the ICD functionality to CRT devices offers a more pronounced survival benefit in men compared with women, as previous research has suggested. Methods Observational multicentre cohort study of 5307 consecutive patients with ischaemic or nonischaemic dilated cardiomyopathy and no history of sustained ventricular arrhythmias having CRT implantation with (cardiac resynchronisation therapy defibrillator (CRT-D), n=4037) or without (cardiac resynchronisation therapy pacemaker (CRT-P), n=1270) defibrillator functionality. Using propensity score (PS) matching and weighting and cause-of-death data, we assessed and compared the outcome of patients with CRT-D versus CRT-P. This analysis was stratified according to sex. Results After a median follow-up of 34 months (interquartile range 22-60 months) no survival advantage, of CRT-D versus CRT-P was observed in both men and women after PS matching (HR=0.95, 95% CI 0.77 to 1.16, p=0.61, and HR=1.30, 95% CI 0.83 to 2.04, p=0.25, respectively). With inverse-probability weighting, a benefit of CRT-D was seen in male patients (HR 0.78, 95% CI 0.65 to 0.94, p=0.012) but not in women (HR 0.87, 95% CI 0.63 to 1.19, p=0.43). The excess unadjusted mortality of patients with CRT-P compared with CRT-D was related to sudden cardiac death in 7.4% of cases in men but only 2.2% in women. Conclusions In primary prevention patients with CRT indication, the addition of a defibrillator might convey additional benefit only in well-selected male patients.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Providência, RuiNational Health Service Trust, NHS England (författare)
  • Duehmke, RudolfPapworth Hospital (författare)
  • Boveda, SergeClinique Pasteur, Toulouse (författare)
  • Marijon, EloiHôpital Européen Georges-Pompidou (författare)
  • Reitan, ChristianSkåne University Hospital(Swepub:lu)med-cr2 (författare)
  • Borgquist, RasmusLund University,Lunds universitet,Arrhytmias and Cardiac Device treatment,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-rbo (författare)
  • Klug, DidierLille University Hospital (författare)
  • Defaye, PascalGrenoble University Hospital (författare)
  • Sadoul, NicolasUniversity Hospital of Nancy (författare)
  • Deharo, Jean ClaudeLa Timone University Hospital (författare)
  • Sadien, IannishPapworth Hospital (författare)
  • Patel, KiranNational Health Service Trust, NHS England (författare)
  • Looi, Khang LiAuckland City Hospital (författare)
  • Begley, David (författare)
  • Chow, Anthony W.National Health Service Trust, NHS England (författare)
  • Heuzey, Jean Yves LeHôpital Européen Georges-Pompidou (författare)
  • Agarwal, SharadPapworth Hospital (författare)
  • Papworth HospitalNational Health Service Trust, NHS England (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Heart: BMJ103:10, s. 753-7601355-60371468-201X

Internetlänk

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  • Heart (Sök värdpublikationen i LIBRIS)

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