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  • Egesten, ArneLund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund (author)

Localization of granule proteins in human eosinophil bone marrow progenitors

  • Article/chapterEnglish1997

Publisher, publication year, extent ...

  • 1997

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:f5ba5676-26a6-4dae-8c65-775685062312
  • https://lup.lub.lu.se/record/1296414URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Eosinophils have a characteristic content of cationic proteins, stored in core-containing specific granules and released at sites of inflammation; coreless granules (sometimes called primary) are present in eosinophil promyelocytes. In order to determine a possible relationship between the two granule subsets, immunoelectron-microscopic techniques were used to determine the presence and precise intragranular distribution of major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil peroxidase (EPO), and arylsulfatase B of eosinophil granules, as well as the Charcot-Leyden crystal (CLC) protein, in eosinophil progenitors of the bone marrow. MBP, ECP, EPO, and arylsulfatase B were observed in both coreless and core-containing (specific) granules. The difference in the distribution of MBP, having a uniform distribution in coreless granules and a crystalloid distribution in core-containing (specific) granules, could indicate a maturational process of a common organelle. CLC protein was distributed in the cytosol, in the euchromatin of the nuclei, but was also present in a rare granular compartment of both immature and mature eosinophils. The present findings suggest that coreless granules develop into core-containing specific granules.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Calafat, J (author)
  • Weller, P F (author)
  • Knol, E F (author)
  • Janssen, H (author)
  • Walz, T M (author)
  • Olsson, I (author)
  • Lungmedicin, allergologi och palliativ medicinSektion II (creator_code:org_t)

Related titles

  • In:International Archives of Allergy and Immunology114:2, s. 8-1301423-0097

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