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The role of alcohol...
The role of alcohol use and adiposity in serum levels of IL-1RA in depressed patients
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- Archer, Mari (författare)
- Tampere University, Faculty of Medicine and Health Technology, P.O. Box 100, Tampere, 33014, Finland
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- Niemelä, Onni (författare)
- Department of Laboratory Medicine and Medical Research Unit, Seinäjoki Central Hospital and Tampere University, Seinäjoki, 60220, Finland
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- Hämäläinen, Mari (författare)
- The Immunopharmacology Research Group, Tampere University, Faculty of Medicine and Health Technology, and Tampere University Hospital, Tampere, 33014, Finland
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- Moilanen, Eeva (författare)
- The Immunopharmacology Research Group, Tampere University, Faculty of Medicine and Health Technology, and Tampere University Hospital, Tampere, 33014, Finland
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- Leinonen, Esa (författare)
- Tampere University, Faculty of Medicine and Health Technology, P.O. Box 100, 33014 University of Tampere, and Tampere University Hospital, Tampere, 33014, Finland
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- Kampman, Olli (författare)
- Tampere University, Faculty of Medicine and Health Technology, P.O. Box 100, 33014 University of Tampere and Pirkanmaa Hospital District, Department of Psychiatry, Tampere, 33521, Finland
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Tampere University, Faculty of Medicine and Health Technology, PO. Box 100, Tampere, 33014, Finland Department of Laboratory Medicine and Medical Research Unit, Seinäjoki Central Hospital and Tampere University, Seinäjoki, 60220, Finland (creator_code:org_t)
- 2022-03-02
- 2022
- Engelska.
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Ingår i: BMC Psychiatry. - : BioMed Central (BMC). - 1471-244X. ; 22:1
- Relaterad länk:
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https://doi.org/10.1...
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https://bmcpsychiatr...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: The role of Interleukin-1 Receptor antagonist (IL-1Ra), an innate antagonist to pro-inflammatory cytokine IL-1, has attracted increasing attention due to its potential pathogenic and therapeutic implications in depression. However, the role of alcohol and adiposity in modulating IL-1Ra cytokine pathway in depressed patients has remainned unknown. The aim of this study was to follow the changes in IL-1Ra serum levels in depressed patients with or without simultaneous alcohol use disorder (AUD) and different degrees of adiposity during 6 months of follow-up.MATERIALS AND METHODS: A total of 242 patients with depression were followed for 6 months. At baseline 99 patients had simultaneous AUD. Levels of serum IL-1Ra and common mediators of inflammation (IL-6, hs-CRP) were measured. Clinical assessments included Body Mass Index (BMI), Montgomery-Asberg Depression Rating Scale (MADRS) and Alcohol Use Disorders Identification Test (AUDIT) scores.RESULTS: Significant reductions in clinical symptoms and IL-1Ra were observed during 6-month follow-up. In hierarchical linear regression analysis, the effect of MADRS score, age, gender, and smoking had a combined effect of 2.4% in the model. The effect of AUDIT score increased the effect to 4.2% of variance (p = 0.08), whereas adding BMI increased the effect to 18.5% (p < 0.001).CONCLUSION: Adiposity may influence the IL-1Ra anti-inflammatory response in depressed patients, whereas the effect of alcohol consumption in these patients seems insignificant. These findings should be considered in studies on the role of IL-1Ra in depression.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Cytokine
- Ethanol
- Mood disorder
- Obesity
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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