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Chronic inflammation in the etiology of disease across the life span

Furman, David (author)
Austral University, Argentina,Buck Institute for Research on Aging,Stanford University
Campisi, Judith (author)
Lawrence Berkeley National Laboratory,Buck Institute for Research on Aging
Verdin, Eric (author)
Buck Institute for Research on Aging
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Carrera-Bastos, Pedro (author)
Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Skåne University Hospital,Center for Primary Health Care Research
Targ, Sasha (author)
University of California, San Francisco
Franceschi, Claudio (author)
IRCCS Network Of Neuroscience And Neurorehabilitation, Bologna,N. I. Lobachevsky State University of Nizhny Novgorod
Ferrucci, Luigi (author)
National Institute on Aging, United States
Gilroy, Derek W. (author)
University College London
Fasano, Alessio (author)
Harvard Medical School
Miller, Gary W. (author)
Columbia University
Miller, Andrew H. (author)
Emory University
Mantovani, Alberto (author)
Queen Mary University,Humanitas Research Hospital,Humanitas University
Weyand, Cornelia M. (author)
Stanford University
Barzilai, Nir (author)
Yeshiva University
Goronzy, Jorg J. (author)
Stanford University
Rando, Thomas A. (author)
VA Palo Alto Health Care System,Stanford University
Effros, Rita B. (author)
University of California, Los Angeles
Lucia, Alejandro (author)
12 de Octubre University Hospital,European University of Madrid
Kleinstreuer, Nicole (author)
National Institute of Environmental Health Sciences
Slavich, George M. (author)
University of California, Los Angeles
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 (creator_code:org_t)
2019-12-05
2019
English.
In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 25:12, s. 1822-1832
Related links:
http://dx.doi.org/10...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and autoimmune and neurodegenerative disorders. In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress. Furthermore, we suggest potential strategies for advancing the early diagnosis, prevention and treatment of SCI.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

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