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Protein co-expressi...
Protein co-expression network-based profiles revealed from laser-microdissected cancerous cells of lung squamous-cell carcinomas
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- Nishimura, Toshihide (författare)
- St. Marianna University School of Medicine
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- Fujii, Kiyonaga (författare)
- St. Marianna University School of Medicine
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- Nakamura, Haruhiko (författare)
- St. Marianna University School of Medicine
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- Naruki, Saeko (författare)
- St. Marianna University Hospital Kawasaki
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- Sakai, Hiroki (författare)
- St. Marianna University School of Medicine
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- Kimura, Hiroyuki (författare)
- St. Marianna University School of Medicine
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- Miyazawa, Tomoyuki (författare)
- St. Marianna University School of Medicine
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- Takagi, Masayuki (författare)
- St. Marianna University Hospital Kawasaki
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- Furuya, Naoki (författare)
- St. Marianna University School of Medicine
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- Marko-Varga, Gyorgy (författare)
- Lund University,Lunds universitet,Clinical Protein Science and Imaging,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Kato, Harubumi (författare)
- Tokyo Medical University,International University of Health and Welfare
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- Saji, Hisashi (författare)
- St. Marianna University School of Medicine
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St Marianna University School of Medicine St. Marianna University Hospital Kawasaki (creator_code:org_t)
- 2021-10-12
- 2021
- Engelska.
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 11:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- No therapeutic targets have been identified for lung squamous cell cancer (SqCC) which is the second most prevalent lung cancer because its molecular profiles remain unclear. This study aimed to unveil disease-related protein networks by proteomic and bioinformatic assessment of laser-microdissected cancerous cells from seven SqCCs compared with eight representative lung adenocarcinomas. We identified three network modules significant to lung SqCC using weighted gene co-expression network analysis. One module was intrinsically annotated to keratinization and cell proliferation of SqCC, accompanied by hypoxia-induced aerobic glycolysis, in which key regulators were activated (HIF1A, ROCK2, EFNA1-5) and highly suppressed (KMT2D). The other two modules were significant for translational initiation, nonsense-mediated mRNA decay, inhibited cell death, and interestingly, eIF2 signaling, in which key regulators, MYC and MLXIPL, were highly activated. Another key regulator LARP1, the master regulator in cap-dependent translation, was highly suppressed although upregulations were observed for hub proteins including EIF3F and LARP1 targeted ribosomal proteins, among which PS25 is the key ribosomal protein in IRES-dependent translation. Our results suggest an underlying progression mechanism largely caused by switching to the cap-independent, IRES-dependent translation of mRNA subsets encoding oncogenic proteins. Our findings may help to develop therapeutic strategies to improve patient outcomes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- Av författaren/redakt...
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Nishimura, Toshi ...
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Fujii, Kiyonaga
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Nakamura, Haruhi ...
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Naruki, Saeko
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Sakai, Hiroki
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Kimura, Hiroyuki
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visa fler...
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Miyazawa, Tomoyu ...
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Takagi, Masayuki
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Furuya, Naoki
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Marko-Varga, Gyo ...
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Kato, Harubumi
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Saji, Hisashi
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visa färre...
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Lunds universitet